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局部类固醇注射与腕部夹板治疗腕管综合征:一项随机临床试验。

Local steroid injection versus wrist splinting for carpal tunnel syndrome: A randomized clinical trial.

作者信息

So Ho, Chung Vincent C H, Cheng Joseph C K, Yip Ronald M L

机构信息

Kwong Wah Hospital, Tung Wah Group of Hospitals, Hong Kong, China.

The Chinese University of Hong Kong, Tung Wah Group of Hospitals, Hong Kong, China.

出版信息

Int J Rheum Dis. 2018 Jan;21(1):102-107. doi: 10.1111/1756-185X.13162. Epub 2017 Sep 13.

DOI:10.1111/1756-185X.13162
PMID:28901660
Abstract

AIM

We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome (CTS).

METHODS

The well-validated and disease-specific Boston Carpal Tunnel Questionnaire (BCTQ) was employed and its score at 4 weeks after treatment was used as the primary outcome measure. Important secondary outcomes included patient satisfaction, the change of an objective finger dexterity test and the side effects.

RESULTS

Twenty-five patients in the local steroid group and 25 patients in the wrist splinting group completed the study procedures. At 4 weeks after treatment, there was significant improvement of the BTCQ scores in both the steroid group and splinting group. There was improvement of the finger dexterity test only in the steroid group but not in the splinting group. However, there was no statistically significant difference in the changes of BTCQ scores between the two groups after treatment. Patient satisfaction score was higher in the steroid group. Patients in the steroid group took fewer painkillers after treatment. Four patients developed side effects after splinting and three after local steroid injection, which was not statistically significant.

CONCLUSION

Although local steroid injection and nocturnal wrist splinting were equally effective in the treatment of patients with CTS, only the former improved objective hand function. Local steroid injection also resulted in better patient satisfaction and less painkiller use without causing more side effects.

摘要

目的

我们进行了一项前瞻性随机平行临床试验,比较局部注射类固醇与夜间佩戴腕部夹板治疗腕管综合征(CTS)患者的疗效。

方法

采用经过充分验证且针对该疾病的波士顿腕管综合征问卷(BCTQ),并将治疗4周后的问卷得分作为主要结局指标。重要的次要结局包括患者满意度、客观手指灵活性测试的变化以及副作用。

结果

局部注射类固醇组的25例患者和佩戴腕部夹板组的25例患者完成了研究程序。治疗4周后,类固醇组和夹板组的BCTQ评分均有显著改善。仅类固醇组的手指灵活性测试有改善,而夹板组没有。然而,治疗后两组之间BCTQ评分的变化没有统计学上的显著差异。类固醇组的患者满意度得分更高。类固醇组患者治疗后服用的止痛药更少。夹板组有4例患者出现副作用,局部注射类固醇组有3例,差异无统计学意义。

结论

虽然局部注射类固醇和夜间佩戴腕部夹板在治疗CTS患者方面同样有效,但只有前者改善了手部客观功能。局部注射类固醇还带来了更好的患者满意度,减少了止痛药的使用,且未导致更多副作用。

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