亚磺酰基叶立德作为铑(III)催化芳基 C-H 酰甲基化反应中的卡宾前体。
Sulfoxonium Ylides as a Carbene Precursor in Rh(III)-Catalyzed C-H Acylmethylation of Arenes.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
出版信息
Org Lett. 2017 Oct 6;19(19):5256-5259. doi: 10.1021/acs.orglett.7b02531. Epub 2017 Sep 13.
PMID:28901774
Abstract
Sulfoxonium ylides act as an efficient carbene precursor in rhodium(III)-catalyzed C-H acylmethlyation of a variety of arenes assisted by different chelating groups, and both aryl- and alkyl-substituted β-carbonyl sulfoxonium ylides are applicable. The system proceeded under redox-neutral conditions with a broad scope, high efficiency, and functional group tolerance.
摘要
亚磺酰基叶立德在铑（III）催化的各种芳基 C-H 酰甲基化反应中作为有效的卡宾前体，不同的螯合基团辅助，芳基和烷基取代的β-羰基亚磺酰基叶立德均可适用。该体系在氧化还原中性条件下进行，具有广泛的适用范围、高效率和官能团耐受性。
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