Millichamp C J, Singh N N
University of Canterbury, Christchurch, New Zealand.
Res Dev Disabil. 1987;8(2):213-27. doi: 10.1016/0891-4222(87)90005-9.
A double-blind, placebo-controlled study was conducted to assess the effects of intermittent drug therapy on stereotyped and collateral behaviors of six profoundly mentally retarded, institutionalized, adult males. The subjects, all of whom had received antipsychotic medication for more than three years, had their maintenance dosages gradually reduced by almost half during the eight-month study. A multiple baseline across subjects design was utilized to assess drug effects on object and body stereotypy and a range of collateral behaviors. While there was individual variation across behaviors and subjects, the main finding was that despite the marked reduction in medication, there were no general changes of clinical significance in any of the behaviors. This finding is of considerable therapeutic importance since a very large number of institutionalized mentally retarded persons receive similar long-term medication for behavior problems and there is some concern regarding the adverse side effects of such treatment.
进行了一项双盲、安慰剂对照研究，以评估间歇性药物治疗对六名严重智力迟钝、收容机构中的成年男性的刻板行为和附带行为的影响。所有受试者均接受抗精神病药物治疗超过三年，在为期八个月的研究中，他们的维持剂量逐渐减少了近一半。采用跨受试者的多重基线设计来评估药物对物体和身体刻板行为以及一系列附带行为的影响。尽管行为和受试者之间存在个体差异，但主要发现是，尽管药物剂量显著减少，但任何行为均未出现具有临床意义的总体变化。这一发现具有相当大的治疗重要性，因为大量收容机构中的智力迟钝者因行为问题接受类似的长期药物治疗，人们对这种治疗的不良副作用存在一些担忧。
