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牙齿吸收不是遗传性的。

Tooth resorptions are not hereditary.

作者信息

Consolaro Alberto, Bianco Débora de Almeida

机构信息

Bauru School of Dentistry, Universidade de São Paulo (Bauru/SP, Brazil). Ribeirão Preto School of Dentistry, Universidade de São Paulo (Ribeirão Preto/SP, Brazil).

School of Dentistry, Universidade Estadual de Maringá (Maringá/PR, Brazil).

出版信息

Dental Press J Orthod. 2017 Jul-Aug;22(4):22-27. doi: 10.1590/2177-6709.22.4.022-027.oin.

DOI:10.1590/2177-6709.22.4.022-027.oin
PMID:28902245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5573006/
Abstract

Root resorptions caused by orthodontic movement are not supported by consistent scientific evidence that correlate them with heredity, individual predisposition and genetic or familial susceptibility. Current studies are undermined by methodological and interpretative errors, especially regarding the diagnosis and measurements of root resorption from orthopantomographs and cephalograms. Samples are heterogeneous insofar as they comprise different clinical operators, varied types of planning, and in insufficient number, in view of the prevalence of tooth resorptions in the population. Nearly all biological events are coded and managed through genes, but this does not mean tooth resorptions are inherited, which can be demonstrated in heredograms and other methods of family studies. In orthodontic root resorption, one cannot possibly determine percentages of how much would be due to heredity or genetics, environmental factors and unknown factors. There is no need to lay the blame of tooth resorptions on events taking place outside the orthodontic realm since in the vast majority of cases, resorptions are not iatrogenic. In orthodontic practice, when all teeth are analyzed and planned using periapical radiography or computerized tomography, and when considering all predictive factors, tooth resorptions are not iatrogenic in nature and should be considered as one of the clinical events inherent in the treatment applied.

摘要

正畸移动引起的牙根吸收缺乏一致的科学证据支持,这些证据将其与遗传、个体易感性以及遗传或家族易感性联系起来。当前的研究受到方法学和解释性错误的影响,特别是在从全景片和头颅侧位片中诊断和测量牙根吸收方面。样本具有异质性,因为它们包括不同的临床操作者、不同类型的治疗计划,而且鉴于人群中牙齿吸收的普遍性,样本数量不足。几乎所有的生物事件都是通过基因编码和调控的,但这并不意味着牙齿吸收是可遗传的,这一点可以通过系谱图和其他家族研究方法得到证明。在正畸牙根吸收中,不可能确定有多少比例是由遗传或基因、环境因素以及未知因素导致的。没有必要将牙齿吸收归咎于正畸领域之外发生的事件,因为在绝大多数情况下,吸收并非医源性的。在正畸实践中,当使用根尖片或计算机断层扫描对所有牙齿进行分析和规划,并考虑所有预测因素时,牙齿吸收本质上并非医源性的,而应被视为所应用治疗中固有的临床事件之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6f/5573006/9e20367a858a/2176-9451-dpjo-22-04-00022-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6f/5573006/9e20367a858a/2176-9451-dpjo-22-04-00022-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6f/5573006/9e20367a858a/2176-9451-dpjo-22-04-00022-gf1.jpg

相似文献

1
Tooth resorptions are not hereditary.牙齿吸收不是遗传性的。
Dental Press J Orthod. 2017 Jul-Aug;22(4):22-27. doi: 10.1590/2177-6709.22.4.022-027.oin.
2
Orthodontic tooth movement and root resorption with special reference to force magnitude and duration. A clinical and histological investigation in adolescents.正畸牙齿移动与牙根吸收,特别涉及力的大小和持续时间。一项针对青少年的临床与组织学研究。
Swed Dent J Suppl. 1995;105:1-45.
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Apical root resorption after lingual orthodontic therapy.舌侧正畸治疗后的根尖根吸收
J Orofac Orthop. 2003 Nov;64(6):434-42. doi: 10.1007/s00056-003-0243-5.
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Root resorptions induced by genetic disorders: A systematic review.遗传疾病引起的牙根吸收:系统评价。
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Periapical replacement resorption of permanent, vital, endodontically treated incisors after orthodontic movement: report of two cases.正畸移动后恒活髓、经根管治疗的切牙根尖周替代性吸收:两例报告
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Types of root resorptions related to orthodontic treatment.与正畸治疗相关的牙根吸收类型。
Stomatologija. 2019;21(1):22-27.
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Why not to treat the tooth canal to solve external root resorptions? Here are the principles!为什么不通过治疗根管来解决牙根外吸收问题呢?以下是一些原则!
Dental Press J Orthod. 2016 Nov-Dec;21(6):20-25. doi: 10.1590/2177-6709.21.6.020-025.oin.
8
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Orthodontically induced inflammatory root resorptions: a case report.正畸诱导的炎性牙根吸收:一例报告。
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本文引用的文献

1
External apical root resorption concurrent with orthodontic forces: the genetic influence.正畸力作用下的根尖外吸收:遗传影响
Acta Odontol Scand. 2017 May;75(4):280-287. doi: 10.1080/00016357.2017.1294260. Epub 2017 Feb 24.
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Effects of cell-mediated osteoprotegerin gene transfer and mesenchymal stem cell applications on orthodontically induced root resorption of rat teeth.细胞介导的骨保护素基因转移和间充质干细胞应用对大鼠正畸诱导牙根吸收的影响。
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Genetic and clinical risk factors of root resorption associated with orthodontic treatment.
正畸治疗相关牙根吸收的遗传和临床风险因素。
Am J Orthod Dentofacial Orthop. 2016 Aug;150(2):283-9. doi: 10.1016/j.ajodo.2015.12.028.
4
Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia.与正畸治疗同时发生的根尖外吸收(EARR)相关的遗传和治疗相关风险因素。
Orthod Craniofac Res. 2015 Apr;18 Suppl 1(Suppl 1):71-82. doi: 10.1111/ocr.12078.
5
Compression of human primary cementoblasts leads to apoptosis: A possible cause of dental root resorption?人原代成牙骨质细胞受压导致细胞凋亡:牙根吸收的一个可能原因?
J Orofac Orthop. 2014 Nov;75(6):430-45. doi: 10.1007/s00056-014-0237-5. Epub 2014 Oct 26.
6
Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis.白细胞介素-1β +3954多态性与正畸治疗中根尖外吸收风险的Meta分析
Genet Mol Res. 2013 Oct 18;12(4):4678-86. doi: 10.4238/2013.October.18.6.
7
Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption.正畸诱导性根尖牙根吸收中P2X7R、IL-1B、OPG和RANK编码基因的多态性
Oral Dis. 2014 Oct;20(7):659-67. doi: 10.1111/odi.12185. Epub 2013 Oct 31.
8
Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients.骨桥蛋白基因单核苷酸多态性(rs9138、rs11730582)介导正畸患者外部牙根吸收的易感性。
Oral Dis. 2014 Apr;20(3):307-12. doi: 10.1111/odi.12114. Epub 2013 Apr 25.
9
Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth.白细胞介素 1 受体拮抗剂 (IL1RN) 基因变异与牙髓治疗后牙齿正畸性外吸收相关。
Histol Histopathol. 2013 Jun;28(6):767-73. doi: 10.14670/HH-28.767. Epub 2012 Dec 5.
10
IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia.与正畸治疗并发的根尖外吸收相关的白细胞介素1基因多态性
Oral Dis. 2013 Apr;19(3):262-70. doi: 10.1111/j.1601-0825.2012.01973.x. Epub 2012 Aug 6.