影响糖尿病患者白色念珠菌生长速率的营养因素新视角。一项体外研究。
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study.
作者信息
Man Adrian, Ciurea Cristina Nicoleta, Pasaroiu Dan, Savin Ana-Ioana, Toma Felicia, Sular Floredana, Santacroce Luigi, Mare Anca
机构信息
University of Medicine and Pharmacy, Department of Microbiology, Tîrgu Mures, Romania.
University of Medicine and Pharmacy, Tîrgu Mures, Romania.
出版信息
Mem Inst Oswaldo Cruz. 2017 Sep;112(9):587-592. doi: 10.1590/0074-02760170098.
BACKGROUND
The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated.
OBJECTIVES
The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients.
METHODS
The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry.
FINDINGS
We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate.
MAIN CONCLUSIONS
As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites.
背景
白色念珠菌与糖尿病之间的联系已得到广泛认可，但尚未完全阐明。
目的
本研究旨在评估白色念珠菌（CA）在不同浓度葡萄糖和果糖存在下的生长速率，葡萄糖和果糖是糖尿病患者主要的病理生理和营养相关糖类中的两种，以便更好地理解营养获取策略及其与糖尿病患者高血糖状态的可能关系。
方法
通过流式细胞术研究了不同浓度葡萄糖和果糖（1000mg%、500mg%、250mg%和100mg% w/v）对CA生长速率的影响。
研究结果
我们发现葡萄糖浓度与CA生长直接相关，这可能与未控制的糖尿病患者中频繁发生的酵母菌感染有关；我们还表明果糖会抑制CA生长速率。
主要结论
基于我们的假设，该研究表明含果糖的食物可能预防念珠菌病的发生，至少在口腔部位如此。
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