Darwazeh A M, Lamey P J, Samaranayake L P, MacFarlane T W, Fisher B M, Macrury S M, MacCuish A C
Department of Oral Medicine and Pathology, Glasgow Dental Hospital and School.
J Med Microbiol. 1990 Sep;33(1):43-9. doi: 10.1099/00222615-33-1-43.
This study investigated whether oral candida infection in diabetics and adhesion of Candida albicans to buccal epithelial cells in vitro were related. Buccal cells from 50 patients with diabetes mellitus showed a significant increase in adhesion of C. albicans strain CDS 88 compared with those collected from 50 non-diabetic controls matched for age, sex and denture status. Oral candida carriage, candida infection and secretor status were also investigated in both groups. The frequency of carriage was increased, but not significantly, and there was a significantly higher incidence of candida infection in diabetic patients compared with controls. Diabetic patients who were non-secretors had a significantly increased frequency of oral candida carriage.
本研究调查了糖尿病患者的口腔念珠菌感染与白色念珠菌在体外对颊上皮细胞的黏附是否相关。与从50名年龄、性别和义齿状况相匹配的非糖尿病对照者采集的颊细胞相比，50名糖尿病患者的颊细胞显示白色念珠菌CDS 88菌株的黏附显著增加。两组还调查了口腔念珠菌携带情况、念珠菌感染情况和分泌型状态。念珠菌携带频率有所增加，但不显著，与对照组相比，糖尿病患者念珠菌感染的发生率显著更高。非分泌型糖尿病患者口腔念珠菌携带频率显著增加。
