Lindholm C, Bjelkenkrantz K, Hofer P A
Department of Oncology, University of Umeå.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;53(4):257-8. doi: 10.1007/BF02890251.
Single cell DNA cytophotometry was used to characterize seven compound, ten intradermal and six Spitz naevi as well as 23 primary cutaneous malignant melanomas. Compound and intradermal naevi were characterized by a smaller nuclear area than both Spitz naevi and malignant melanomas. Tumour ploidy could not be used as a single criterion of malignancy since both diploid and hyperdiploid melanomas were encountered. The very low mean optical density of Spitz naevi served to distinguish these lesions from malignant melanomas.
采用单细胞DNA细胞光度测定法对7个复合痣、10个皮内痣、6个斯皮茨痣以及23个原发性皮肤恶性黑色素瘤进行特征分析。复合痣和皮内痣的核面积小于斯皮茨痣和恶性黑色素瘤。肿瘤倍性不能作为恶性肿瘤的单一标准，因为同时发现了二倍体和超二倍体黑色素瘤。斯皮茨痣极低的平均光密度有助于将这些病变与恶性黑色素瘤区分开来。
