Steardo L, Barone P, Monteleone P, Iovino M, Cardone G
Department of Neurology, University of Naples, Italy.
Acta Psychiatr Scand. 1987 Aug;76(2):129-33. doi: 10.1111/j.1600-0447.1987.tb02874.x.
The authors attempt to correlate the response to dexamethasone suppression test (DST) with a clinical response to antidepressant drugs in 68 patients with major depression. Antidepressants that influence noradrenergic or serotonergic transmission with relative different potencies were selected and used in standard doses for 6 weeks. The response was evaluated weekly by raters blind to DST results and to antidepressant medications prescribed. The retrospective analysis failed to correlate DST response with outcome of treatment. Therefore the present results suggest that this laboratory test does not help to identify subgroups of depressed patients responding preferentially to various antidepressant drugs.
作者试图将68例重度抑郁症患者对地塞米松抑制试验（DST）的反应与对抗抑郁药物的临床反应相关联。选择了对去甲肾上腺素能或5-羟色胺能传递有不同相对效力影响的抗抑郁药，并以标准剂量使用6周。由对DST结果和所开抗抑郁药物不知情的评估者每周对反应进行评估。回顾性分析未能将DST反应与治疗结果相关联。因此，目前的结果表明，这项实验室检查无助于识别对各种抗抑郁药物有优先反应的抑郁症患者亚组。
