Zhang Hong-He, Tan Lin-Xiang, Hao Wei, Deng Qi-Jian
Mental Health Institute of the Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, Hunan, China.
Xiamen Xianyue Hospital, Xiamen Mental Health Center, Xiamen, Fujian, China.
Oncotarget. 2017 Jun 27;8(33):54046-54053. doi: 10.18632/oncotarget.18681. eCollection 2017 Aug 15.
In this study, we analyzed the efficacy and feasibility of a community-based integrated heroin addiction treatment model in Chinese patients. The 210 heroin addicts belonging to six Chinese communities received an integrated biopsychosocial intervention that included pharmacological treatment, counseling and social assistance. High proportions of study participants were retained at the 12-month (91.9%; 193/210) and 24-month (88.1%; 185/210) follow-up visits. The number of morphine-positive subjects declined from 61.4% at baseline to 36.2% and 30.5% (=52.01; <0.001) after 12 and 24 months, respectively. The crime rate decreased from 32.4% at baseline to 2.2% and 1.6% (=7.84; <0.001) after 12 and 24 months, respectively. The number of patients that were employed increased from 24.3% at baseline to 37.8% and 50.8% after 12 and 24 months, respectively (=41.68; <0.001). Addiction-related issues and mental health status improved according to Addiction Severity Index (ASI) and Symptom Checklist-90 (SCL-90). We therefore conclude that this community-based, integrated heroin addiction treatment model is highly feasible with high treatment retention, reduced drug use, a lower crime rate, improved health and increased employment.
在本研究中,我们分析了一种基于社区的综合海洛因成瘾治疗模式在中国患者中的疗效和可行性。来自六个中国社区的210名海洛因成瘾者接受了包括药物治疗、咨询和社会援助在内的综合生物心理社会干预。在12个月(91.9%;193/210)和24个月(88.1%;185/210)的随访中,研究参与者的保留率很高。吗啡阳性受试者的数量从基线时的61.4%分别降至12个月和24个月后的36.2%和30.5%(=52.01;<0.001)。犯罪率从基线时的32.4%分别降至12个月和24个月后的2.2%和1.6%(=7.84;<0.001)。就业患者的数量从基线时的24.3%分别增至12个月和24个月后的37.8%和50.8%(=41.68;<0.001)。根据成瘾严重程度指数(ASI)和症状自评量表90(SCL-90),与成瘾相关的问题和心理健康状况有所改善。因此,我们得出结论,这种基于社区的综合海洛因成瘾治疗模式具有很高的可行性,治疗保留率高,药物使用减少,犯罪率降低,健康状况改善,就业增加。