Sun Zhenqiang, Wang Fuqi, Zhou Quanbo, Yang Shuaixi, Sun Xiantao, Wang Guixian, Li Zhen, Zhang Zhiyong, Song Junmin, Liu Jinbo, Yuan Weitang
Department of Anorectal Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Oncotarget. 2017 May 17;8(33):54672-54682. doi: 10.18632/oncotarget.17931. eCollection 2017 Aug 15.
We explored the prognostic significance of the pre-operative-to-post-operative serum carcinoembryonic antigen (pre-post-CEA) ratio in colorectal cancer (CRC). We detected pre- and post-operative CEA levels in 2035 CRC patients surgically treated at First Affiliated Hospital of Zhengzhou University between June 2001 and June 2011. Univariate analysis revealed the pre-post-CEA ratio is associated with distant metastasis and degree of tumor differentiation (both < 0.05). Multivariate analysis showed that the pre-post-CEA ratio is associated with lymphatic and distant metastasis, tumor-node-metastasis (TNM) stage and degree of tumor differentiation (all < 0.01). The pre-CEA levels, pre-post-CEA ratios, distant metastasis, TNM stage and degree of tumor differentiation were all associated with 5-yr overall survival (all < 0.05) based on multivariate analysis. Consequently, pre-CEA levels, pre-post-CEA ratios, distant metastasis and TNM stage are independent risk factors for CRC. We have thus demonstrated that the pre-post-CEA ratio is a prognostic indicator for CRC patients.
我们探讨了术前至术后血清癌胚抗原（术前-术后CEA）比值在结直肠癌（CRC）中的预后意义。我们检测了2001年6月至2011年6月在郑州大学第一附属医院接受手术治疗的2035例CRC患者的术前和术后CEA水平。单因素分析显示术前-术后CEA比值与远处转移及肿瘤分化程度相关（均P<0.05）。多因素分析表明术前-术后CEA比值与淋巴转移、远处转移、肿瘤-淋巴结-转移（TNM）分期及肿瘤分化程度相关（均P<0.01）。基于多因素分析，术前CEA水平、术前-术后CEA比值、远处转移、TNM分期及肿瘤分化程度均与5年总生存率相关（均P<0.05）。因此，术前CEA水平、术前-术后CEA比值、远处转移及TNM分期是CRC的独立危险因素。我们由此证明术前-术后CEA比值是CRC患者的一个预后指标。
