Zhang Fan, Zhang Yuanyuan, Zhao Weiwei, Deng Kui, Wang Zhuozhong, Yang Chunyan, Ma Libing, Openkova Margarita S, Hou Yan, Li Kang
Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Harbin Medical University, Harbin, P.R. China.
Oncotarget. 2017 May 23;8(21):35460-35472. doi: 10.18632/oncotarget.16727.
Colorectal cancer (CRC) remains an incurable disease. There are no effective noninvasive techniques that have achieved colorectal cancer (CRC) diagnosis, prognosis, survival and recurrence in clinic. To investigate colorectal cancer metabolism, we perform an electronic literature search, from 1998 to January 2016, for studies evaluating the metabolomic profile of patients with CRC regarding the diagnosis, recurrence, prognosis/survival, and systematically review the twenty-three literatures included. QUADOMICS tool was used to assess the quality of them. We highlighted the metabolism perturbations based on metabolites and pathway. Metabolites related to cellular respiration, carbohydrate, lipid, protein and nucleotide metabolism were significantly altered in CRC. Altered metabolites were also related to prognosis, survival and recurrence of CRC. This review could represent the most comprehensive information and summary about CRC metabolism to date. It certificates that metabolomics had great potential on both discovering clinical biomarkers and elucidating previously unknown mechanisms of CRC pathogenesis.
结直肠癌（CRC）仍然是一种无法治愈的疾病。目前尚无有效的非侵入性技术可用于临床诊断、预测结直肠癌（CRC）的预后、生存及复发情况。为研究结直肠癌的代谢情况，我们进行了一项电子文献检索，检索时间跨度为1998年至2016年1月，旨在查找评估CRC患者代谢组学特征与诊断、复发、预后/生存关系的研究，并对纳入的23篇文献进行系统综述。使用QUADOMICS工具评估这些文献的质量。我们基于代谢物和代谢途径突出了代谢紊乱情况。与细胞呼吸、碳水化合物、脂质、蛋白质及核苷酸代谢相关的代谢物在CRC中发生了显著变化。这些改变的代谢物还与CRC的预后、生存及复发相关。本综述可能代表了迄今为止关于CRC代谢最全面的信息和总结。它证明代谢组学在发现临床生物标志物及阐明CRC发病机制中先前未知的机制方面具有巨大潜力。
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