Blessing W W, Hedger S C, Joh T H, Willoughby J O
Department of Medicine, Flinders University of South Australia, Bedford Park.
Brain Res. 1987 Sep 1;419(1-2):336-40. doi: 10.1016/0006-8993(87)90604-4.
We have identified, in the rabbit medulla and pons, neurons which project to the C1-region of the rostral ventrolateral medulla. By combining tyrosine hydroxylase immunohistochemistry with retrograde transport of Fluoro-Gold we determined whether any of the retrogradely labelled neurons synthesize catecholamines. The only doubly labelled cells were located in the area postrema. No other group of catecholamine-synthesizing neurons in either the medulla or the pons was found to project to the C1-area of the rostral ventrolateral medulla. Pharmacological agents which lower arterial pressure by stimulating adrenoceptors in the rostral ventrolateral medulla may act on receptors which are not innervated by catecholamine-synthesizing perikarya located outside the C1-region.
我们已在兔延髓和脑桥中鉴定出投射至延髓头端腹外侧C1区的神经元。通过将酪氨酸羟化酶免疫组织化学与荧光金逆行转运相结合，我们确定了是否有任何逆行标记的神经元合成儿茶酚胺。仅有的双标细胞位于最后区。在延髓或脑桥中，未发现其他合成儿茶酚胺的神经元群投射至延髓头端腹外侧的C1区。通过刺激延髓头端腹外侧的肾上腺素能受体来降低动脉血压的药物，可能作用于C1区以外的合成儿茶酚胺的胞体未支配的受体。
