Voitenkov Voitenkov Vladislav, Andrey Klimkin, Natalia Skripchenko, Anastasia Aksenova
Department of Functional Diagnostics, Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russia.
J Pediatr Neurosci. 2017 Apr-Jun;12(2):144-148. doi: 10.4103/jpn.JPN_128_16.
The diagnosis of polyneuropathy may be challenging at the early stages of the disease. Despite electromyography (EMG) efficacy in the establishment of polyneuropathy diagnosis, in some cases, results are dubious and neurophysiologists may implement additional techniques to ensure that conduction is affected.
The aim of the study was to evaluate motor-evoked potential (MEP) characteristics in children with acute inflammatory demyelinating polyneuropathy (AIDP).
The study was conducted at a pediatric research and clinical center for infectious diseases.
Twenty healthy children (7-14 years old) without signs of neurological disorders were enrolled as controls. Thirty-seven patients (8-13 years old) with AIDP were enrolled as the main group. EMG and transcranial magnetic stimulation (TMS) were performed on the 3-7 days from the onset of the first symptoms.
Descriptive statistics and Student's -test were used. Bonferroni method was applied to implement appropriate corrections for multiple comparisons.
Significant differences between children with AIDP and controls on latencies of both cortical and lumbar MEPs were registered. Cortical MEP shapes were disperse in 100% of the cases and lumbar MEPs were disperse in 57% of the cases.
Diagnostic TMS on the early stage of the AIDP in children may be implemented as the additional tool. The main finding in this population is lengthening of the latency of cortical and lumbar MEPs. Disperse shape of the lumbar MEPs may be used as the early sign of the acute demyelization.
多发性神经病在疾病早期的诊断可能具有挑战性。尽管肌电图（EMG）在确立多发性神经病诊断方面具有有效性，但在某些情况下，结果仍不明确，神经生理学家可能会采用其他技术来确保传导受到影响。
本研究的目的是评估急性炎症性脱髓鞘性多发性神经病（AIDP）患儿的运动诱发电位（MEP）特征。
该研究在一家儿科传染病研究与临床中心进行。
招募20名无神经系统疾病体征的健康儿童（7 - 14岁）作为对照组。招募37名AIDP患儿（8 - 13岁）作为主要研究组。在首次出现症状后的3 - 7天进行肌电图和经颅磁刺激（TMS）检查。
采用描述性统计和学生t检验。应用Bonferroni方法对多重比较进行适当校正。
记录到AIDP患儿与对照组在皮质和腰部运动诱发电位潜伏期方面存在显著差异。100%的病例中皮质运动诱发电位形态离散，57%的病例中腰部运动诱发电位形态离散。
儿童AIDP早期的诊断性经颅磁刺激可作为一种辅助工具实施。该人群的主要发现是皮质和腰部运动诱发电位潜伏期延长。腰部运动诱发电位的离散形态可作为急性脱髓鞘的早期征象。
