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携带花青碱基替代物的红色发射三联体形成肽核酸探针用于双链RNA的荧光传感。

Red-emissive triplex-forming PNA probes carrying cyanine base surrogates for fluorescence sensing of double-stranded RNA.

作者信息

Chiba Toshiki, Sato Takaya, Sato Yusuke, Nishizawa Seiichi

机构信息

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.

出版信息

Org Biomol Chem. 2017 Sep 26;15(37):7765-7769. doi: 10.1039/c7ob02077e.

DOI:10.1039/c7ob02077e
PMID:28905972
Abstract

Red-emissive fluorescent probes have been developed by integration of quinoline blue or thiazole red as the base surrogate into triplex-forming PNAs, allowing selective sensing of a sequence of double-stranded RNA.

摘要

通过将喹啉蓝或噻唑红作为碱基替代物整合到形成三链的肽核酸（PNA）中，已开发出红色发射荧光探针，可对双链RNA序列进行选择性传感。

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