一种能够同时识别小干扰RNA的3'端突出端和双链序列的荧光肽核酸探针的设计。
Design of a fluorogenic PNA probe capable of simultaneous recognition of 3'-overhang and double-stranded sequences of small interfering RNAs.
作者信息
Tanabe Takaaki, Sato Takaya, Sato Yusuke, Nishizawa Seiichi
机构信息
Department of Chemistry, Graduate School of Science, Tohoku University Sendai 980-8578 Japan
出版信息
RSC Adv. 2018 Dec 18;8(73):42095-42099. doi: 10.1039/c8ra08759h. eCollection 2018 Dec 12.
Abstract
We developed a new fluorescent peptide nucleic acid (PNA) probe, COT probe, capable of simultaneous recognition of 3'-overhang and double stranded sequences of target small interfering RNA (siRNA).
摘要
我们开发了一种新型荧光肽核酸（PNA）探针，即COT探针，它能够同时识别靶标小干扰RNA（siRNA）的3'突出端和双链序列。
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