醇、卤代烃和无味亚硫酸钠在无过渡金属条件下的水相反应：通过双重 C-S 键形成合成不对称芳基硫醚。
Aqueous Reaction of Alcohols, Organohalides, and Odorless Sodium Thiosulfate under Transition-Metal-Free Conditions: Synthesis of Unsymmetrical Aryl Sulfides via Dual C-S Bond Formation.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou 215123, P. R. China.
Department of Chemistry and Chemical Engineering, Jining University , Qufu 273155, P. R. China.
出版信息
J Org Chem. 2017 Oct 6;82(19):10174-10180. doi: 10.1021/acs.joc.7b01653. Epub 2017 Sep 25.
A transition-metal-free process for the synthesis of unsymmetrical aryl sulfides via dual C-S bond formation by a one-pot three-component reaction of alcohols, organohalides, and odorless sodium thiosulfate in water has been developed. In addition, the aryl sulfides could also be prepared by the reaction of the corresponding alcohols and Bunte salts under the identical conditions. This protocol provides a green and efficient manner for the construction of various unsymmetrical aryl sulfides.
一种通过醇、卤代烃和无味的硫代硫酸钠在水中的一锅三步反应，通过双 C-S 键形成来合成不对称芳基硫醚的无过渡金属方法已经开发出来。此外，在相同条件下，相应的醇和 Bunte 盐也可以反应得到芳基硫醚。该方案为构建各种不对称芳基硫醚提供了一种绿色高效的方法。
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