无过渡金属和氧化剂参与的芳基腙与二硫化物的交叉偶联：碱促进的不对称芳基硫醚合成。
Transition-Metal-Free and Oxidant-Free Cross-Coupling of Arylhydrazines with Disulfides: Base-Promoted Synthesis of Unsymmetrical Aryl Sulfides.
机构信息
Seika Corporation , 1-1-82 Kozaika, Wakayama 641-0007, Japan.
Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University , 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
出版信息
J Org Chem. 2017 Jul 7;82(13):6647-6655. doi: 10.1021/acs.joc.7b00767. Epub 2017 Jun 23.
PMID:28616985
Abstract
A novel synthesis of unsymmetrical aryl sulfides, which requires no transition metal catalyst and no oxidant, was developed. This base-promoted cross-coupling reaction proceeded using arylhydrazines and 1 equiv amount of disulfides under inert gas conditions to afford the unsymmetrical aryl sulfides in good yields.
摘要
开发了一种新型的不对称芳基硫醚合成方法，该方法无需过渡金属催化剂和氧化剂。在惰性气体条件下，该碱促进的交叉偶联反应使用芳基腙和 1 当量的二硫化物进行，以良好的收率得到不对称芳基硫醚。
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