四丁基铵碘化物催化/水辅助的双C-S键形成：一种通过无金属三组分反应高效合成硫化物的方法。
TBAI-Catalyzed/Water-Assisted Double C-S Bond Formations: An Efficient Approach to Sulfides through Metal-Free Three-Component Reactions.
作者信息
Chu Xue-Qiang, Xu Xiao-Ping, Ji Shun-Jun
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.
出版信息
Chemistry. 2016 Sep 26;22(40):14181-5. doi: 10.1002/chem.201603099. Epub 2016 Aug 17.
An aqueous catalytic method for double C-S bond formations that involves alcohol derivatives, organic halides, and sodium thiosulfate has been developed. A diverse range of functionalized sulfides, including pharmaceutical and biological derivatives, can be obtained in an efficient and eco-friendly manner under air. The mechanistic studies revealed that this tetrabutylammonium-iodide-catalyzed/water-assisted reaction generated a mercaptan species as the key intermediate.
已开发出一种涉及醇衍生物、有机卤化物和硫代硫酸钠的用于形成双C-S键的水相催化方法。在空气中，可以高效且环保的方式获得包括药物和生物衍生物在内的多种功能化硫化物。机理研究表明，这种碘化四丁铵催化/水辅助反应生成硫醇物种作为关键中间体。
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