Department of Chemistry, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Lett. 2017 Oct 6;19(19):5458-5461. doi: 10.1021/acs.orglett.7b02778. Epub 2017 Sep 14.
We report here a manganese-catalyzed C-H methylation reaction of considerable substrate scope, using MeMgBr, a catalytic amount of MnCl·2LiCl, and an organic dihalide oxidant. The reaction features ambient temperature, low catalyst loading, typically 1%, high catalytic turnover reaching 5.9 × 10, and no need for an extraneous ligand and illustrates a unique catalytic use of simple manganese salts for C-H activation, which so far has relied on catalysis by manganese carbonyls.
我们在此报告了一种锰催化的 C-H 甲基化反应，具有广泛的底物范围，使用 MeMgBr、催化量的 MnCl·2LiCl 和有机二卤化物氧化剂。该反应具有环境温度、低催化剂负载（通常为 1%）、高催化周转率（达到 5.9×10）的特点，不需要外加配体，并说明了简单锰盐在 C-H 活化中的独特催化用途，迄今为止，这一用途一直依赖于锰羰基化合物的催化。
