Zipkin Frida B, Falciglia Grace A, Kuhnell Pierce, Haynes Erin N
Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Kettering Laboratory, Cincinnati, OH 45267, USA.
Department of Nutritional Sciences, University of Cincinnati, 3202 Eden Avenue, Cincinnati, OH 45267, USA.
Int J Environ Res Public Health. 2017 Sep 14;14(9):1060. doi: 10.3390/ijerph14091060.
Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children's growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum. This study utilized a subset of the Communities Actively Researching Exposure Study (CARES) population residing in Guernsey County, Ohio. Dietary Mn was not correlated with either blood or hair Mn; however, dietary Mn and serum ferritin were significantly correlated, with a correlation coefficient of 0.51, < 0.01. Moreover, dietary Fe and serum ferritin were also significantly correlated, with a correlation coefficient of 0.51, < 0.01. This FFQ is a valid measurement tool for Fe intake as measured by serum ferritin; however, Mn intake did not correlate with either blood or hair Mn.
锰（Mn）是一种必需营养素，但过度接触会导致神经毒性。鉴于锰在饮食中的必要性，尤其是在儿童生长发育期间，对可能接触工业源锰的人群进行膳食锰摄入量的量化至关重要。锰的膳食吸收与铁（Fe）储备呈负相关，但目前尚无用于评估膳食锰和铁摄入量的食物频率问卷（FFQ）。本研究的目的是通过将锰和铁的估计摄入量与生物标志物（血液和头发中的锰以及血清中的铁）进行比较，来开发和评估用于测量儿科膳食锰和铁摄入量的FFQ的有效性。本研究利用了居住在俄亥俄州根西县的社区积极研究暴露研究（CARES）人群的一个子集。膳食锰与血液或头发中的锰均无相关性；然而，膳食锰与血清铁蛋白显著相关，相关系数为0.51，P<0.01。此外，膳食铁与血清铁蛋白也显著相关，相关系数为0.51，P<0.01。作为通过血清铁蛋白测量的铁摄入量，该FFQ是一种有效的测量工具；然而，锰摄入量与血液或头发中的锰均无相关性。
