Oduola A M, Milhous W K, Salako L A, Walker O, Desjardins R E
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Lancet. 1987 Dec 5;2(8571):1304-5. doi: 10.1016/s0140-6736(87)91195-0.
West African isolates of Plasmodium falciparum were more susceptible to chloroquine but less susceptible to mefloquine than were Southeast Asian isolates. The West African isolates were more sensitive to halofantrine than to mefloquine. Since neither mefloquine nor halofantrine has been used in West Africa, the findings suggest that P falciparum may be inherently resistant to mefloquine and that mefloquine should be introduced cautiously to West Africa. Moreover, halofantrine may be of greater value than mefloquine for controlling multidrug-resistant falciparum malaria in West Africa.
与东南亚分离株相比，西非恶性疟原虫分离株对氯喹更敏感，但对甲氟喹较不敏感。西非分离株对卤泛群比对甲氟喹更敏感。由于甲氟喹和卤泛群在西非均未使用过，这些发现表明恶性疟原虫可能对甲氟喹具有内在抗性，并且在西非引入甲氟喹时应谨慎。此外，在控制西非耐多药恶性疟方面，卤泛群可能比甲氟喹更具价值。
