Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
J Org Chem. 2017 Oct 20;82(20):11206-11211. doi: 10.1021/acs.joc.7b01701. Epub 2017 Sep 29.
Dehydroxytrifluoromethylthiolation of alcohols with a PhPCFCO/S/F system is described. Difluorocarbene generated from PhPCFCO would readily combine with elemental sulfur to furnish S═CF. S═CF can be considered as a bifunctional intermediate, activating alcohol and providing scaffold for CFS formation, thus allowing for the convenient dehydroxytrifluoromethylthiolation of alcohols.
描述了 PhPCFCO/S/F 体系中醇的去羟基三氟甲基化反应。PhPCFCO 产生的二氟卡宾很容易与元素硫结合生成 S═CF。S═CF 可以被认为是一种双功能中间体，既能活化醇，又能为 CFS 形成提供支架，从而实现了醇的方便的去羟基三氟甲基化反应。
