College of Chemistry and Materials Science, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, China.
Chem Commun (Camb). 2019 Jan 29;55(10):1410-1413. doi: 10.1039/c8cc09719d.
Cu-Promoted difluorocarbene-derived trifluoromethylselenolation of benzyl halides with the Ph3P+CF2CO2-/Se/F- system is described. Three new carbon-heteroatom bonds, a Se-CF2 bond, SeCF2-F bond, and C-SeCF3 bond, were sequentially formed in the reaction. This work represents the first trifluoromethylselenolation protocol involving an external fluoride for the generation of the key intermediate, CF3Se- anion.
Cu 促进的二氟卡宾衍生的三氟甲基硒化反应，用于苄基卤化物与 Ph3P+CF2CO2-/Se/F-体系的反应，已被描述。在反应中，三个新的碳杂原子键，即 Se-CF2 键、SeCF2-F 键和 C-SeCF3 键，依次形成。这项工作代表了首例涉及外部氟化物生成关键中间体 CF3Se-阴离子的三氟甲基硒化反应。
