Yeragani V K, Chaitin P
Lafayette Clinic, Detroit, Michigan 48207.
Med Hypotheses. 1987 Oct;24(2):143-9. doi: 10.1016/0306-9877(87)90097-1.
A subgroup of patients with schizophrenia or other psychoses may have an increased PGE receptor sensitivity in the brain, which may be due to low levels of PGE. Some of these patients may develop a severe dopaminergic blockade when given neuroleptics which stimulate PGE synthesis. This may lead to the symptoms of neuroleptic malignant syndrome. Calcium channel blockers inhibit the prostaglandin output caused by norepinephrine and these agents may prove useful in the treatment of neuroleptic malignant syndrome.
精神分裂症或其他精神病患者的一个亚组可能大脑中前列腺素E（PGE）受体敏感性增加，这可能是由于PGE水平较低所致。这些患者中的一些人在给予刺激PGE合成的抗精神病药物时，可能会出现严重的多巴胺能阻断。这可能导致抗精神病药物恶性综合征的症状。钙通道阻滞剂可抑制去甲肾上腺素引起的前列腺素分泌，这些药物可能在抗精神病药物恶性综合征的治疗中证明有用。
