Vassallo S U, Delaney K A
Bellevue Hospital, Department of Emergency Medicine, New York City, New York 10016.
J Toxicol Clin Toxicol. 1989;27(4-5):199-224. doi: 10.3109/15563658908994419.
In summary, a number of pharmacologic agents interfere with the body's ability to maintain normal body temperature during exercise or under conditions of environmental heat stress. Life threatening elevation of body temperature may occur. Regardless of the predisposing cause of heatstroke, the final common pathway is heat injury to tissues causing cell death. Rapid cooling of the patient must take precedence and elucidation of the pathophysiologic disturbance is secondary to the accomplishment of this goal.
总之，许多药物会干扰身体在运动期间或环境热应激条件下维持正常体温的能力。可能会出现危及生命的体温升高。无论中暑的诱发原因是什么，最终的共同途径是组织热损伤导致细胞死亡。必须优先对患者进行快速降温，阐明病理生理紊乱在实现这一目标之后。
