Charnchai Pattra, Jantama Sirima Suvarnakuta, Jantama Kaemwich
Metabolic Engineering Research Unit, School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, 111 University Avenue, Suranaree, Muang, Nakhon Ratchasima 30000, Thailand.
Division of Biopharmacy, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Sathonlamark Road, Warin chamrap, Ubon Ratchathani 34190, Thailand.
FEMS Microbiol Lett. 2017 Sep 15;364(17). doi: 10.1093/femsle/fnx180.
In this study, Bifidobacterium animalis subsp. lactis BF052 was demonstrated the growth capability in soymilk and could be thus supplemented as a probiotic starter that employed soymilk as one of its food vehicles. The complete genome sequence of BF052 was therefore determined to understand the genetic basis of BF052 as a technological and functional probiotic starter. The whole genome sequence of BF052 consists of a circular genome of 1938 624 bp with a G+C content of 60.50%. This research highlights relevant genes involving in its adaptive responses to industrial and/or environmental stresses and utilization of α-galacto-oligosaccharides in BF052 strain compared with other representative bifidobacterial genomes.
在本研究中,动物双歧杆菌乳亚种BF052被证明具有在豆浆中的生长能力,因此可以作为一种使用豆浆作为其食物载体之一的益生菌发酵剂进行补充。因此,测定了BF052的完整基因组序列,以了解BF052作为一种技术和功能性益生菌发酵剂的遗传基础。BF052的全基因组序列由一个1938624 bp的环状基因组组成,G+C含量为60.50%。与其他代表性双歧杆菌基因组相比,本研究突出了BF052菌株中涉及其对工业和/或环境压力的适应性反应以及α-低聚半乳糖利用的相关基因。