Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico; Departamento de Farmacobiología, CINVESTAV-Sede Sur, Mexico.
Departamento de Farmacobiología, CINVESTAV-Sede Sur, Mexico.
Mol Cell Endocrinol. 2018 May 15;467:42-48. doi: 10.1016/j.mce.2017.09.010. Epub 2017 Sep 12.
The Coolidge effect is the renewal of sexual behavior after the presentation of a novel sexual partner and possibly occurs as the result of habituation and dishabituation processes. This re-motivation to copulate is well studied in males and is commonly related to sexual satiety, which involves several neurobiological changes in steroid receptors and their mRNA expression in the CNS. On the other hand, there are few reports studying sexual novelty in females and have been limited to behavioral aspects. Here we report that the levels of rat proceptive behavior, a sign of sexual motivation, declines after 4 h of continuous mating, particularly in females that were unable to regulate the time of mating. Such reduction was not accompanied by changes in lordosis, suggesting that they were not due to the vanishing of the endocrine optimal milieu necessary for the expression of both components of sexual behavior in the female rat. These and previous data support important differences between sexual behavior in both sexes that would result in natural divergences in the Coolidge effect expression. We here also review some reports in humans showing peculiarities between the pattern of habituation and dishabituation in women and men. This is a growing research field that needs emphasis in female subjects.
酷儿效应是指在呈现新的性伴侣后，性行为的恢复，可能是由于习惯化和去习惯化过程。这种重新交配的动机在雄性中得到了很好的研究，通常与性饱足有关，性饱足涉及中枢神经系统中类固醇受体及其 mRNA 表达的几种神经生物学变化。另一方面，关于女性的性新奇性研究很少，并且仅限于行为方面。在这里，我们报告说，大鼠求爱行为（性动机的标志）在连续交配 4 小时后下降，特别是在无法调节交配时间的雌性大鼠中。这种减少并没有伴随着发情行为的变化，这表明它们不是由于雌性大鼠性行为的两个组成部分表达所必需的内分泌最佳环境的消失所致。这些和以前的数据支持了两性之间性行为的重要差异，这将导致酷儿效应表达的自然差异。我们还回顾了一些人类报告，这些报告显示了女性和男性之间习惯化和去习惯化模式的特殊性。这是一个需要在女性受试者中强调的研究领域。
