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JT间期各段的心率依赖性。

Heart rate dependency of JT interval sections.

作者信息

Hnatkova Katerina, Johannesen Lars, Vicente Jose, Malik Marek

机构信息

National Heart and Lung Institute, Imperial College, London, United Kingdom.

Division of Clinical Pharmacology I, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

出版信息

J Electrocardiol. 2017 Nov-Dec;50(6):814-824. doi: 10.1016/j.jelectrocard.2017.08.005. Epub 2017 Aug 9.

Abstract

BACKGROUND

Little experience exists with the heart rate correction of J-Tpeak and Tpeak-Tend intervals.

METHODS

In a population of 176 female and 176 male healthy subjects aged 32.3±9.8 and 33.1±8.4years, respectively, curve-linear and linear relationship to heart rate was investigated for different sections of the JT interval defined by the proportions of the area under the vector magnitude of the reconstructed 3D vectorcardiographic loop.

RESULTS

The duration of the JT sub-section between approximately just before the T peak and almost the T end was found heart rate independent. Most of the JT heart rate dependency relates to the beginning of the interval. The duration of the terminal T wave tail is only weakly heart rate dependent.

CONCLUSIONS

The Tpeak-Tend is only minimally heart rate dependent and in studies not showing substantial heart rate changes does not need to be heart rate corrected. For any correction formula that has linear additive properties, heart rate correction of JT and JTpeak intervals is practically the same as of the QT interval. However, this does not apply to the formulas in the form of Int/RR since they do not have linear additive properties.

摘要

背景

关于J-Tpeak和Tpeak-Tend间期的心率校正经验较少。

方法

在分别为176名女性和176名男性的健康受试者群体中,年龄分别为32.3±9.8岁和33.1±8.4岁,根据重建的三维心电向量环的向量幅值下面积的比例定义JT间期的不同部分,研究其与心率的曲线线性和线性关系。

结果

发现在T波峰前片刻至几乎T波结束之间的JT子段持续时间与心率无关。JT间期对心率的依赖性大多与间期开始部分有关。终末T波尾部的持续时间仅与心率有微弱的相关性。

结论

Tpeak-Tend间期对心率的依赖性极小,在未显示心率有实质性变化的研究中无需进行心率校正。对于任何具有线性相加特性的校正公式,JT和JTpeak间期的心率校正实际上与QT间期的心率校正相同。然而,这不适用于Int/RR形式的公式,因为它们不具有线性相加特性。

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