From the TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Circ Res. 2017 Sep 15;121(7):711-721. doi: 10.1161/CIRCRESAHA.117.311812.
The nonischemic cardiomyopathies are a diverse group of cardiac disorders that frequently cause heart failure and death and are now recognized with increasing frequency. There has been substantial progress in the clinical recognition and understanding of the natural history of these conditions. Well-established and new techniques of cardiac imaging are also helpful in this regard. Basic scientists are elucidating the pathogenesis and pathobiology of individual cardiomyopathies. In this compendium, some of the most important advances in this field are reviewed. Scientific opportunities to enhance further collaborative research to accelerate progress are identified.
非缺血性心肌病是一组多样化的心脏疾病,常导致心力衰竭和死亡,且其发病率正在不断增加。目前,临床医生对这些疾病的自然病程有了更深入的认识。心脏影像学的新技术也为此提供了帮助。基础科学家正在阐明各种心肌病的发病机制和病理生物学。在本综述中,我们回顾了该领域的一些最重要的进展,并确定了进一步加强合作研究以加速进展的科学机遇。