Chen Xuechen, Zhang Yuan, Chen Qian, Li Qing, Li Yanping, Ling Wenhua
From the Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China (X.C., Q.C., Y.L., W.L.); Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China (X.C., Q.C., Y.L., W.L.); Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, China (Y.Z.); and Department of Epidemiology, School of Public Health, Guilin Medical University, China (Q.L.).
Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2213-2219. doi: 10.1161/ATVBAHA.117.309700. Epub 2017 Sep 14.
The present study was designed to evaluate the association of circulating fetuin-A with cardiovascular disease (CVD) and all-cause mortality.
We measured plasma fetuin-A in 1620 patients using an enzyme-linked immunosorbent assay kit. The patients were members of the Guangdong coronary artery disease cohort and were recruited between October 2008 and December 2011. Cox regression models were used to estimate the association between plasma fetuin-A and the risk of mortality. A total of 206 deaths were recorded during a median follow-up of 5.9 years, 146 of whom died from CVD. The hazard ratios for the second and third tertiles of the fetuin-A levels (using the first tertile as a reference) were 0.65 (95% confidence interval, 0.44-0.96) and 0.51 (95% confidence interval, 0.33-0.78) for CVD mortality (=0.005) and 0.65 (95% confidence interval, 0.47-0.91) and 0.48 (95% confidence interval, 0.33-0.70) for all-cause mortality (<0.001), respectively.
Lower plasma fetuin-A levels were associated with an increased risk of all-cause and CVD mortality in patients with coronary artery disease independently of traditional CVD risk factors.
本研究旨在评估循环中的胎球蛋白-A与心血管疾病（CVD）及全因死亡率之间的关联。
我们使用酶联免疫吸附测定试剂盒对1620例患者的血浆胎球蛋白-A进行了检测。这些患者是广东冠心病队列的成员，于2008年10月至2011年12月期间招募。采用Cox回归模型来估计血浆胎球蛋白-A与死亡风险之间的关联。在中位随访5.9年期间共记录了206例死亡，其中146例死于心血管疾病。对于心血管疾病死亡率（P=0.005），胎球蛋白-A水平处于第二和第三三分位数（以第一三分位数作为参照）时的风险比分别为0.65（95%置信区间为0.44-0.96）和0.51（95%置信区间为0.33-0.78）；对于全因死亡率（P<0.001），风险比分别为0.65（95%置信区间为0.47-0.91）和0.48（95%置信区间为0.33-0.70）。
在冠心病患者中，较低的血浆胎球蛋白-A水平与全因及心血管疾病死亡风险增加相关，且独立于传统的心血管疾病风险因素。
