血清胎球蛋白-A受营养状况影响，作为冠状动脉疾病的新型生物标志物
Serum Fetuin-A Affected by Nutritional Status as a Novel Biomarker for Coronary Artery Disease.
作者信息
Icer Mehmet Arif, Yıldıran Hilal, Sahinarslan Asife, Topal Salih, Yalcın Yakup
机构信息
Department of Nutrition and Dietetics, Faculty of Health Sciences, Amasya University, Amasya.
Department of Nutrition and Dietetics, Faculty of Health Sciences.
出版信息
Acta Cardiol Sin. 2025 May;41(3):335-345. doi: 10.6515/ACS.202505_41(3).20241201A.
BACKGROUND
The mechanisms underlying coronary artery disease (CAD), which is characterized by atherosclerotic plaque accumulation in the arteries, are still not fully understood. The role of serum fetuin-A level in the development of CAD and its effects on other risk factors are important research topics that have attracted increasing attention. The aim of this study was to evaluate serum fetuin-A level and the effects of nutritional status on serum fetuin-A concentration in CAD patients.
METHODS
The study was carried out on 47 male participants (case group) who were newly diagnosed with CAD by conventional coronary angiography and 40 male participants without CAD (control group) aged between 35-75 years. Biochemical parameters, anthropometric measurements and three-day food records of all participants were recorded. In addition, Gensini and SYNTAX scores were calculated using angiography images to determine the extent and severity of CAD.
RESULTS
Serum fetuin-A concentration in the case group was higher than that in the control group (p < 0.001). Waist circumference, hip circumference, waist/height ratio, Gensini and SYNTAX scores and serum fetuin-A levels in the participants in the case group were positively correlated (p < 0.05). In addition, there were negative correlations between serum fetuin-A concentration and dietary polyunsaturated fatty acids, omega-6 fatty acids, vitamin E, vitamin B, folate, potassium, and selenium intake in the participants in the case group (p < 0.05).
CONCLUSIONS
The results of the study indicate that high serum fetuin-A levels may be a risk factor for the development of CAD, and that nutritional status might affect serum fetuin-A level.
背景
冠状动脉疾病（CAD）以动脉粥样硬化斑块积聚为特征，其潜在机制仍未完全明确。血清胎球蛋白-A水平在CAD发生发展中的作用及其对其他危险因素的影响是备受关注的重要研究课题。本研究旨在评估CAD患者的血清胎球蛋白-A水平以及营养状况对血清胎球蛋白-A浓度的影响。
方法
本研究纳入了47名经传统冠状动脉造影新诊断为CAD的男性参与者（病例组）和40名年龄在35 - 75岁之间无CAD的男性参与者（对照组）。记录了所有参与者的生化参数、人体测量数据和三日饮食记录。此外，利用血管造影图像计算Gensini和SYNTAX评分，以确定CAD的范围和严重程度。
结果
病例组血清胎球蛋白-A浓度高于对照组（p < 0.001）。病例组参与者的腰围、臀围、腰高比、Gensini和SYNTAX评分与血清胎球蛋白-A水平呈正相关（p < 0.05）。此外，病例组参与者血清胎球蛋白-A浓度与膳食多不饱和脂肪酸、ω-6脂肪酸、维生素E、维生素B、叶酸、钾和硒摄入量呈负相关（p < 0.05）。
结论
研究结果表明，血清胎球蛋白-A水平升高可能是CAD发生的一个危险因素，且营养状况可能影响血清胎球蛋白-A水平。
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