小胶质细胞吞噬作用和炎症介质在睡眠障碍病理生理学中的作用
Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders.
作者信息
Nadjar Agnes, Wigren Henna-Kaisa M, Tremblay Marie-Eve
机构信息
Nutrition et Neurobiologie Intégrée, UMR 1286, Institut National de la Recherche AgronomiqueBordeaux, France.
Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux UniversityBordeaux, France.
出版信息
Front Cell Neurosci. 2017 Aug 30;11:250. doi: 10.3389/fncel.2017.00250. eCollection 2017.
Abstract
Sleep serves crucial learning and memory functions in both nervous and immune systems. Microglia are brain immune cells that actively maintain health through their crucial physiological roles exerted across the lifespan, including phagocytosis of cellular debris and orchestration of neuroinflammation. The past decade has witnessed an explosive growth of microglial research. Considering the recent developments in the field of microglia and sleep, we examine their possible impact on various pathological conditions associated with a gain, disruption, or loss of sleep in this focused mini-review. While there are extensive studies of microglial implication in a variety of neuropsychiatric and neurodegenerative diseases, less is known regarding their roles in sleep disorders. It is timely to stimulate new research in this emergent and rapidly growing field of investigation.
摘要
睡眠在神经系统和免疫系统中发挥着至关重要的学习和记忆功能。小胶质细胞是大脑免疫细胞，通过其在整个生命周期中发挥的关键生理作用积极维持健康，包括吞噬细胞碎片和协调神经炎症。过去十年见证了小胶质细胞研究的迅猛发展。鉴于小胶质细胞和睡眠领域的最新进展，我们在这篇重点小型综述中探讨它们对与睡眠增加、紊乱或缺失相关的各种病理状况可能产生的影响。虽然有大量关于小胶质细胞在多种神经精神疾病和神经退行性疾病中的作用的研究，但关于它们在睡眠障碍中的作用却知之甚少。在这个新兴且迅速发展的研究领域激发新的研究恰逢其时。
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