Tetik Kerem, Seçkin Kerem Doğa, Karslı Fatih Mehmet, Sarıaslan Seval, Çakmak Bülent, Danışman Nuri
Zekai Tahir Burak Womens Health Teaching and Research Hospital, Clinic of Obstetrics and Gyncology, Ankara, Turkey.
Tokat Gaziosmanpaşa Universty Faculty of Medicine, Department of Obstetrics and Gyncology, Tokat, Turkey.
Turk J Obstet Gynecol. 2014 Dec;11(4):228-232. doi: 10.4274/tjod.39260. Epub 2014 Dec 15.
The purpose of the present study was to assess the effect of D-dimer and fibrinogen levels in maternal serum as a marker for detection of intrauterine growth restriction (IUGR).
Two hundred-thirty four pregnant women who get pregnancy follow-up and delivery in the tertiary hospital between January 2011 and December 2011 were admitted to the study. Pregnant women were divided into two groups; group-1: 117 pregnants complicated with IUGR and group-2: 117 healthy pregnants without IUGR as control. Serum D-dimer and fibrinogen levels of all pregnant women were measured in the third trimester. The levels of D-dimer and fibrinogen were compared between two groups.
There is no significant difference between the groups for age, body mass index before pregnancy, smoking and gestational weeks (p>0.05). Gravidity, parity, number of children and maternal serum fibrinogen level were detected significantly different between the groups (p<0.001). D-dimer level was not significantly different between the groups (p=0.183), but fibrinogen level in group-1 was found higher than group-2.
Serum fibrinogen level was found higher in pregnant women complicated with IUGR but D-dimer level was not different between the groups. Although serum D-dimer should not be used as a marker for detection of IUGR, serum fibrinogen may be used.
本研究旨在评估孕妇血清中D - 二聚体和纤维蛋白原水平作为检测胎儿宫内生长受限（IUGR）标志物的效果。
选取2011年1月至2011年12月在三级医院接受孕期随访并分娩的234例孕妇纳入研究。孕妇分为两组；第1组：117例合并IUGR的孕妇；第2组：117例无IUGR的健康孕妇作为对照组。在孕晚期测量所有孕妇的血清D - 二聚体和纤维蛋白原水平。比较两组之间D - 二聚体和纤维蛋白原水平。
两组在年龄、孕前体重指数、吸烟情况和孕周方面无显著差异（p>0.05）。两组在妊娠次数、产次、子女数和孕妇血清纤维蛋白原水平方面存在显著差异（p<0.001）。两组之间D - 二聚体水平无显著差异（p = 0.183），但第1组的纤维蛋白原水平高于第2组。
合并IUGR的孕妇血清纤维蛋白原水平较高，但两组之间D - 二聚体水平无差异。虽然血清D - 二聚体不应作为检测IUGR的标志物，但血清纤维蛋白原可能可用。
