Gadhok Amita K, Sharma Tarun K, Sinha Maheep, Khunteta Rakesh, Vardey Satish K, Sahni Poonam, Sankhla Manisha
Clin Lab. 2017 May 1;63(5):941-945. doi: 10.7754/Clin.Lab.2017.161120.
The weight of the infant at birth is a powerful predictor of infant growth and survival and is dependent on maternal health and nutrition during pregnancy. Pregnant women have a defense mechanism against increased oxidative stress composed of antioxidant enzymes and natural antioxidant vitamins like vitamin C and E. Therefore, we evaluated whether differences exist in serum levels of vitamin C and E in pregnant women complicated with intrauterine growth restriction (IUGR).
This study was done in 180 pregnant women admitted in hospital for delivery. Blood samples were collected and stored at -70°C until analysis. Among 180 pregnant women 150 were identified as IUGR pregnant women according to the weight of the infant and the remaining 30 normal healthy pregnant women as controls. Blood hemoglobin and serum vitamin C and E levels were measured in both groups.
The mean hemoglobin concentration was significantly decreased (p< 0.001) in IUGR pregnant women (8.92 ± 1.35 g/dL) as compared to the normal healthy pregnant women (10.51 ± 1.04 g/dL) in our study. The serum concentration of vitamin C in the group of pregnant women with IUGR was 0.54 ± 0.15 mg/dL, whereas in the group of normal healthy pregnant women it was 0.91 ± 0.23 mg/dL. The serum vitamin E level in the normal healthy pregnant women group was 1.22 ± 0.35 mg/dL and 0.65 ± 0.24 mg/dL in IUGR pregnant women group. The serum vitamin C and E level in IUGR pregnant women group was found to be significantly decreased as compared to the normal healthy pregnant women group.
The study indicates the importance of natural antioxidants vitamin C and E against increased oxidative stress in pregnancies complicated with IUGR. Therefore, it may be useful to measure serum vitamin C and E levels in IUGR pregnant women. This study suggests further research to investigate the role of these natural antioxidant vitamins in fetal growth at various gestation stages.
婴儿出生时的体重是婴儿生长和存活的有力预测指标，且取决于孕期母亲的健康和营养状况。孕妇有一种由抗氧化酶以及维生素C和E等天然抗氧化维生素组成的防御机制，可抵御氧化应激的增加。因此，我们评估了合并宫内生长受限（IUGR）的孕妇血清中维生素C和E水平是否存在差异。
本研究对180名入院待产的孕妇进行。采集血样并在-70°C保存直至分析。在180名孕妇中，根据婴儿体重，150名被确定为IUGR孕妇，其余30名正常健康孕妇作为对照。两组均测量了血红蛋白以及血清维生素C和E水平。
在我们的研究中，与正常健康孕妇（10.51±1.04 g/dL）相比，IUGR孕妇（8.92±1.35 g/dL）的平均血红蛋白浓度显著降低（p<0.001）。IUGR孕妇组血清维生素C浓度为0.54±0.15 mg/dL，而正常健康孕妇组为0.91±0.23 mg/dL。正常健康孕妇组血清维生素E水平为1.22±0.35 mg/dL，IUGR孕妇组为0.65±0.24 mg/dL。与正常健康孕妇组相比，IUGR孕妇组血清维生素C和E水平显著降低。
该研究表明天然抗氧化剂维生素C和E在合并IUGR的妊娠中对抗氧化应激增加的重要性。因此，测量IUGR孕妇血清维生素C和E水平可能有用。本研究建议进一步开展研究，以探究这些天然抗氧化维生素在不同妊娠阶段对胎儿生长的作用。
