宫颈管搔刮术及CA-125测定在子宫内膜浆液性癌中的疗效：病例系列及文献综述
Efficacy of endocervical curettage and CA-125 measurement in endometrial serous carcinoma: A case series and literature review.
作者信息
İyibozkurt Ahmet Cem, Doğan Murat, Baştu Ercan, Sözen Hamdullah, Vatansever Doğan, Topuz Samet, Berkman Sinan
机构信息
İstanbul University İstanbul Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.
出版信息
Turk J Obstet Gynecol. 2015 Sep;12(3):164-167. doi: 10.4274/tjod.69926. Epub 2015 Sep 15.
OBJECTIVE
This is a case series and literature review of patients with endometrial serous carcinoma (ESC) in which endocervical curettage (ECC) and CA-125 measurement were utilized as a diagnostic procedure in preoperative staging.
MATERIALS AND METHODS
The patients were treated in the gynecologic oncology clinic of İstanbul University Faculty of Medicine between January 2005, and January 2015. A total of 37 patients were included in the final analysis.
RESULTS
ECC accurately predicted ESC in 22 patients (59.5%). The mean pre-operative serum CA-125 level was 73.24±3.30 IU/mL; pre-operative serum CA-125 levels were elevated above 35 IU/mL in 25 patients (69%).
CONCLUSION
ECC is an acceptable diagnostic tool to predict the presence or absence of cervical involvement in endometrial cancer. On the other hand, its accuracy in specific subgroups requires further analysis in carefully designed prospective studies. Furthermore, pre-operative serum CA-125 levels may be important for management and counseling in the subgroup of women with ESC.
目的
这是一项关于子宫内膜浆液性癌（ESC）患者的病例系列研究及文献综述，其中宫颈刮除术（ECC）和CA - 125检测被用作术前分期的诊断程序。
材料与方法
患者于2005年1月至2015年1月在伊斯坦布尔大学医学院妇科肿瘤门诊接受治疗。最终分析共纳入37例患者。
结果
ECC准确预测了22例患者（59.5%）的ESC。术前血清CA - 125平均水平为73.24±3.30 IU/mL；25例患者（69%）术前血清CA - 125水平高于35 IU/mL。
结论
ECC是预测子宫内膜癌宫颈受累情况的一种可接受的诊断工具。另一方面，其在特定亚组中的准确性需要在精心设计的前瞻性研究中进一步分析。此外，术前血清CA - 125水平对于ESC女性亚组的管理和咨询可能很重要。
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