Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic Stroke/Transient Ischemic Attack.

BACKGROUND

The correlation between platelet function and recurrent ischemic stroke or TIA remains uncertain.

OBJECTIVE

To investigate two inductive agents to detect platelet functions and assess associations with recurrent ischemic stroke/TIA.

METHOD

The study included 738 ischemic stroke/TIA patients. On days 0, 3, and 9 after antiplatelet therapy, platelet function tests were determined by maximum aggregation rate (MAR) using a PL-11 platelet function analyzer and phase matching reagents. Two induction agents were used: arachidonic acid (AA) and adenosine diphosphate (ADP). At 3-month follow-up, recurrence of stroke/TIA was recorded.

RESULT

Cut-off values of adequate platelet function inhibition were MAR < 35% and MAR < 35%. Data showed that antiplatelet therapy could reduce the maximum aggregation rate. More importantly, adequate platelet function inhibition of either MAR or MAR was not associated with the recurrence of stroke/TIA, but adequate platelet function inhibition of not only MAR but also MAR predicts lower recurrence (0/121 (0.00%) versus 18/459 (3.92%), = 0.0188).

CONCLUSION

The platelet function tested by PL-11 demonstrated that adequate inhibition of both MAR and MAR could predict lower risk of ischemic stroke/TIA recurrence.