通过可变剪接产生蛋白质异构体多样性：机制及生物学意义 - Suppr

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Generation of protein isoform diversity by alternative splicing: mechanistic and biological implications.

作者信息

Andreadis A, Gallego M E, Nadal-Ginard B

机构信息

Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115.

出版信息

Annu Rev Cell Biol. 1987;3:207-42. doi: 10.1146/annurev.cb.03.110187.001231.

DOI:10.1146/annurev.cb.03.110187.001231

PMID:2891362

Abstract

摘要

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Generation of protein isoform diversity by alternative splicing: mechanistic and biological implications.

作者信息

Andreadis A, Gallego M E, Nadal-Ginard B

机构信息

Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115.

出版信息

Annu Rev Cell Biol. 1987;3:207-42. doi: 10.1146/annurev.cb.03.110187.001231.

DOI:10.1146/annurev.cb.03.110187.001231

PMID:2891362

Abstract

摘要

相似文献

Generation of protein isoform diversity by alternative splicing: mechanistic and biological implications.

Annu Rev Cell Biol. 1987;3:207-42. doi: 10.1146/annurev.cb.03.110187.001231.

The generation of protein isoform diversity by alternative RNA splicing.

Soc Gen Physiol Ser. 1994;49:105-15.

Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes.

Annu Rev Biochem. 1987;56:467-95. doi: 10.1146/annurev.bi.56.070187.002343.

Integrative visual analysis of the effects of alternative splicing on protein domain interaction networks.

J Integr Bioinform. 2008 Aug 25;5(2):101. doi: 10.2390/biecoll-jib-2008-101.

Complex transcriptional units: diversity in gene expression by alternative RNA processing.

Annu Rev Biochem. 1986;55:1091-117. doi: 10.1146/annurev.bi.55.070186.005303.

Molecular genetics of transformer, a genetic switch controlling sexual differentiation in Drosophila.

Dev Genet. 1989;10(3):143-54. doi: 10.1002/dvg.1020100304.

Structural genomics analysis of alternative splicing and application to isoform structure modeling.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18920-5. doi: 10.1073/pnas.0506770102. Epub 2005 Dec 14.

Sequence conservation, relative isoform frequencies, and nonsense-mediated decay in evolutionarily conserved alternative splicing.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12813-8. doi: 10.1073/pnas.0506139102. Epub 2005 Aug 25.

Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2.

J Cell Sci. 2007 Jan 15;120(Pt 2):309-19. doi: 10.1242/jcs.03344. Epub 2007 Jan 2.

SR protein and snRNP requirements for assembly of the Rous sarcoma virus negative regulator of splicing complex in vitro.

Virology. 1998 Mar 1;242(1):211-20. doi: 10.1006/viro.1997.8983.

引用本文的文献

Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures.

Nat Methods. 2024 Oct;21(10):1947-1957. doi: 10.1038/s41592-024-02409-0. Epub 2024 Sep 18.

RNA and neuronal function: the importance of post-transcriptional regulation.

Oxf Open Neurosci. 2022 Jul 7;1:kvac011. doi: 10.1093/oons/kvac011. eCollection 2022.

Autophagy regulation by RNA alternative splicing and implications in human diseases.

Nat Commun. 2022 May 18;13(1):2735. doi: 10.1038/s41467-022-30433-1.

A broad analysis of splicing regulation in yeast using a large library of synthetic introns.

PLoS Genet. 2021 Sep 27;17(9):e1009805. doi: 10.1371/journal.pgen.1009805. eCollection 2021 Sep.

A tool for analyzing and visualizing ribo-seq data at the isoform level.

BMC Bioinformatics. 2021 May 25;22(Suppl 10):271. doi: 10.1186/s12859-021-04192-7.

Quantifying splice-site usage: a simple yet powerful approach to analyze splicing.

NAR Genom Bioinform. 2021 May 14;3(2):lqab041. doi: 10.1093/nargab/lqab041. eCollection 2021 Jun.

Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain.

Elife. 2019 Apr 12;8:e38619. doi: 10.7554/eLife.38619.

Alternative Splicing in Apicomplexan Parasites.

mBio. 2019 Feb 19;10(1):e02866-18. doi: 10.1128/mBio.02866-18.

Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer.

Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S132-S144. doi: 10.1074/mcp.RA118.001278. Epub 2019 Jan 25.

PLoS One. 2012;7(6):e31260. doi: 10.1371/journal.pone.0031260. Epub 2012 Jun 22.