Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Nat Commun. 2022 May 18;13(1):2735. doi: 10.1038/s41467-022-30433-1.
Autophagy and RNA alternative splicing are two evolutionarily conserved processes involved in overlapping physiological and pathological processes. However, the extent of functional connection is not well defined. Here, we consider the role for alternative splicing and generation of autophagy-related gene isoforms in the regulation of autophagy in recent work. The impact of changes to the RNA alternative splicing machinery and production of alternative spliced isoforms on autophagy are reviewed with particular focus on disease relevance. The use of drugs targeting both alternative splicing and autophagy as well as the selective regulation of single autophagy-related protein isoforms, are considered as therapeutic strategies.
自噬和 RNA 可变剪接是两个进化上保守的过程，涉及重叠的生理和病理过程。然而，其功能联系的程度尚不清楚。在这里，我们考虑了可变剪接和自噬相关基因亚型的产生在最近的工作中对自噬的调节作用。特别关注疾病相关性，综述了 RNA 可变剪接机制的变化和可变剪接亚型的产生对自噬的影响。还考虑了靶向可变剪接和自噬的药物的使用以及单个自噬相关蛋白亚型的选择性调节作为治疗策略。
