Jones J E, Hunter J M, Utting J E
University Department of Anaesthesia, Royal Liverpool Hospital.
Br J Anaesth. 1987 Nov;59(11):1454-8. doi: 10.1093/bja/59.11.1454.
Recovery from neuromuscular block produced by vecuronium was studied in 50 patients using electromyography and the train-of-four technique. Twenty patients received neostigmine 2.5 mg, 10 when the initial response of the train-of-four was 50% of control and 10 when it was 10%. Neostigmine 5 mg was investigated in a similar manner and in 10 patients spontaneous recovery was studied. In all patients the time to 70% recovery of the initial response and of the train-of-four ratio was followed. Neostigmine significantly reduced the time to 70% recovery of both ratios with both degrees of block, but neostigmine 5.0 mg did not give a substantially more rapid recovery than 2.5 mg. No evidence of a neostigmine-induced block was encountered. neostigmine 2.5 mg was rapidly effective in antagonizing vecuronium-induced block, even when initial recovery was only slight: there was no advantage in using neostigmine 5.0 mg.
采用肌电图和四个成串刺激技术，对50例患者维库溴铵所致神经肌肉阻滞的恢复情况进行了研究。20例患者接受2.5mg新斯的明治疗，其中10例四个成串刺激的初始反应为对照值的50%时给药，另10例在该反应为10%时给药。以类似方式对5mg新斯的明进行了研究，并对10例患者的自主恢复情况进行了研究。观察了所有患者初始反应及四个成串刺激比值恢复至70%所需的时间。新斯的明显著缩短了两种阻滞程度下两种比值恢复至70%所需的时间，但5.0mg新斯的明并未比2.5mg带来明显更快的恢复。未发现新斯的明诱导阻滞的证据。2.5mg新斯的明即使在初始恢复轻微时，也能迅速有效地拮抗维库溴铵诱导的阻滞：使用5.0mg新斯的明并无优势。
