Biomaterials Laboratory, Instituto Militar de Engenharia, Rio de Janeiro, RJ, 2290-270, Brazil.
Laboratory of Experimental Surgery, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, 20561-030, Brazil.
J Mater Sci Mater Med. 2017 Sep 15;28(10):164. doi: 10.1007/s10856-017-5977-5.
The purpose of this work was to investigate the influence of acid treatment on the surface properties and in vivo performance of titanium grade 5 (Ti6Al4V) alloy. Mini-implants with surface treatment were inserted into New Zealand rabbit tibia for 1, 4 and 8 weeks. SEM analysis showed intercommunicated micropores in acid treated samples. AFM showed micron and sub-micron roughness. The thickness of the titanium oxide layer increased with surface treatment, with a significant reduction of Al and V concentration. Acid treated implant removal torque was larger than without treatment. The implants/bone interface of acid treated implants showed dense adhered Ca/P particles with spreading osteoblasts after 4 weeks and newly formed bone trabeculae after 8 weeks. Analysis of rabbit blood that received treated implant showed lower Al and V contents at all times. Acid treatment improved surface morphology and mechanical stability, which allowed initial events of osseointegration, while Al-V ion release was reduced. GRAPHICAL ABTSRACT.
本工作旨在研究酸处理对钛 5 级（Ti6Al4V）合金表面性能和体内性能的影响。经表面处理的微型植入物被插入新西兰兔胫骨中 1、4 和 8 周。SEM 分析显示酸处理样品中有相互连通的微孔。AFM 显示微米和亚微米粗糙度。钛氧化物层的厚度随表面处理而增加，Al 和 V 浓度显著降低。酸处理后植入物的去除扭矩大于未处理组。酸处理植入物的植入物/骨界面在 4 周时显示出密集附着的 Ca/P 颗粒，并有扩散的成骨细胞，8 周时出现新形成的骨小梁。接受处理植入物的兔子血液分析显示，所有时间的 Al 和 V 含量都较低。酸处理改善了表面形态和机械稳定性，从而允许初始的骨整合事件发生，同时减少了 Al-V 离子的释放。
