SIDT2将细胞外双链RNA转运至细胞质以进行天然免疫识别。
SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition.
作者信息
Nguyen Tan A, Smith Blake R C, Tate Michelle D, Belz Gabrielle T, Barrios Marilou H, Elgass Kirstin D, Weisman Alexandra S, Baker Paul J, Preston Simon P, Whitehead Lachlan, Garnham Alexandra, Lundie Rachel J, Smyth Gordon K, Pellegrini Marc, O'Keeffe Meredith, Wicks Ian P, Masters Seth L, Hunter Craig P, Pang Ken C
机构信息
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
出版信息
Immunity. 2017 Sep 19;47(3):498-509.e6. doi: 10.1016/j.immuni.2017.08.007. Epub 2017 Sep 12.
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral immunity.
双链RNA（dsRNA）是病毒感染的常见副产物，可作为抗病毒免疫的有效触发因子。在线虫秀丽隐杆线虫中，sid-1编码一种dsRNA转运蛋白，该蛋白在整个动物进化过程中高度保守，但SID-1及其直系同源物的生理作用仍不清楚。在这里，我们表明哺乳动物SID-1的直系同源物SIDT2是将内化的细胞外dsRNA从内吞小室转运到细胞质中以激活免疫所必需的。暴露于细胞外dsRNA、脑心肌炎病毒（EMCV）和单纯疱疹病毒1型（HSV-1）的Sidt2缺陷小鼠显示抗病毒细胞因子的产生受损，并且在EMCV和HSV-1的情况下存活率降低。因此，SIDT2保留了其秀丽隐杆线虫直系同源物的dsRNA转运活性，并且这种转运对抗病毒免疫很重要。
Zotero 插件