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因果关系、构造函数和代码。

Causation, constructors and codes.

作者信息

Hofmeyr Jan-Hendrik S

机构信息

Centre for Complex Systems in Transition and Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa.

出版信息

Biosystems. 2018 Feb;164:121-127. doi: 10.1016/j.biosystems.2017.09.008. Epub 2017 Sep 13.

Abstract

Relational biology relies heavily on the enriched understanding of causal entailment that Robert Rosen's formalisation of Aristotle's four causes has made possible, although to date efficient causes and the rehabilitation of final cause have been its main focus. Formal cause has been paid rather scant attention, but, as this paper demonstrates, is crucial to our understanding of many types of processes, not necessarily biological. The graph-theoretic relational diagram of a mapping has played a key role in relational biology, and the first part of the paper is devoted to developing an explicit representation of formal cause in the diagram and how it acts in combination with efficient cause to form a mapping. I then use these representations to show how Von Neumann's universal constructor can be cast into a relational diagram in a way that avoids the logical paradox that Rosen detected in his own representation of the constructor in terms of sets and mappings. One aspect that was absent from both Von Neumann's and Rosen's treatments was the necessity of a code to translate the description (the formal cause) of the automaton to be constructed into the construction process itself. A formal definition of codes in general, and organic codes in particular, allows the relational diagram to be extended so as to capture this translation of formal cause into process. The extended relational diagram is used to exemplify causal entailment in a diverse range of processes, such as enzyme action, construction of automata, communication through the Morse code, and ribosomal polypeptide synthesis through the genetic code.

摘要

关系生物学在很大程度上依赖于对因果蕴含的深入理解,而这得益于罗伯特·罗森对亚里士多德四因说的形式化,尽管到目前为止,动力因和目的因的复兴一直是其主要关注点。形式因受到的关注相对较少,但正如本文所表明的,它对于我们理解许多类型的过程至关重要,这些过程不一定是生物学过程。映射的图论关系图在关系生物学中发挥了关键作用,本文的第一部分致力于在图中开发形式因的明确表示,以及它如何与动力因结合以形成映射。然后,我使用这些表示来说明冯·诺依曼的通用构造器如何能够以一种避免罗森在其用集合和映射表示构造器时所发现的逻辑悖论的方式被转化为关系图。冯·诺依曼和罗森的处理中都缺少的一个方面是需要一个代码,将待构建自动机的描述(形式因)转化为构建过程本身。一般代码,特别是有机代码的形式定义,使得关系图得以扩展,从而能够捕捉形式因到过程的这种转化。扩展后的关系图被用于举例说明各种过程中的因果蕴含,如酶的作用、自动机的构建、通过摩尔斯电码的通信以及通过遗传密码的核糖体多肽合成。

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