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生物学从物理学中的动态涌现:通过生物分子的分支因果关系。

The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules.

作者信息

Ellis George F R, Kopel Jonathan

机构信息

Mathematics Department, University of Cape Town, Cape Town, South Africa.

Texas Tech University Health Sciences Center (TTUHSC), Lubbock, TX, United States.

出版信息

Front Physiol. 2019 Jan 25;9:1966. doi: 10.3389/fphys.2018.01966. eCollection 2018.

Abstract

Biology differs fundamentally from the physics that underlies it. This paper proposes that the essential difference is that while physics at its fundamental level is Hamiltonian, in biology, once life has come into existence, causation of a contextual branching nature occurs at every level of the hierarchy of emergence at each time. The key feature allowing this to happen is the way biomolecules such as voltage-gated ion channels can act to enable branching logic to arise from the underlying physics, despite that physics being of a deterministic nature. Much randomness occurs at the molecular level, which enables higher level functions to select lower level outcomes according to higher level needs. Intelligent causation occurs when organisms engage in deduction, enabling prediction and planning. This is possible because ion channels enable action potentials to propagate in axons. The further key feature is that such branching biological behavior acts down to cause the underlying physical interactions to also exhibit a contextual branching behavior.

摘要

生物学与作为其基础的物理学在本质上有所不同。本文提出,本质区别在于,虽然物理学在其基础层面是哈密顿式的,但在生物学中,一旦生命诞生,在每次涌现层次结构的每个层面上,都会随时发生具有情境分支性质的因果关系。使得这种情况能够发生的关键特征是,诸如电压门控离子通道之类的生物分子能够起作用,使分支逻辑从基础物理学中产生,尽管该物理学具有确定性本质。在分子层面会发生大量随机性,这使得更高层次的功能能够根据更高层次的需求选择更低层次的结果。当生物体进行推理从而实现预测和规划时,就会出现智能因果关系。这之所以可能,是因为离子通道使动作电位能够在轴突中传播。另一个关键特征是,这种分支生物行为向下作用,导致基础物理相互作用也呈现出情境分支行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b7e/6355675/f4f8d5ebf010/fphys-09-01966-g0001.jpg

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