与系统性硬化症相关且涉及抗RNA聚合酶III抗体的癌症
[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].
作者信息
Monfort J-B, Mathian A, Amoura Z, Francès C, Barbaud A, Senet P
机构信息
Service de dermatologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
Service de médecine interne, hôpital Pitié-Salpétrière, 47-83, boulevard de l'hôpital, 75013 Paris, France.
出版信息
Ann Dermatol Venereol. 2018 Jan;145(1):33-36. doi: 10.1016/j.annder.2017.08.005. Epub 2017 Sep 13.
BACKGROUND
The incidence of cancer is increased in patients with systemic sclerosis (SSc). Further, recent studies have also shown that the presence of anti-RNA polymerase III antibodies is associated with a higher incidence of cancer in this population.
PATIENTS AND METHODS
Herein we present the cases of two men aged 56 and 23 years presenting SSc without anti-Scl70 or anti-centromere antibodies but with anti-RNA polymerase III antibodies. Clinical symptoms led us to prescribe more laboratory exams and both patients were diagnosed with cancer of the nasopharyngeal area.
DISCUSSION
Anti-RNA polymerase III antibodies are useful for SSc diagnosis in patients without anti-centromere or anti-Scl70 antibodies. Their presence must lead physicians to screen for associated cancer, even in the absence of clinical signs.
背景
系统性硬化症（SSc）患者的癌症发病率会升高。此外，最近的研究还表明，抗RNA聚合酶III抗体的存在与该人群中较高的癌症发病率相关。
患者与方法
在此，我们报告了两名分别为56岁和23岁男性的病例，他们患有系统性硬化症，无抗Scl70或抗着丝点抗体，但有抗RNA聚合酶III抗体。临床症状促使我们安排了更多实验室检查，两名患者均被诊断为鼻咽癌。
讨论
抗RNA聚合酶III抗体对于无抗着丝点或抗Scl70抗体的系统性硬化症患者的诊断很有用。即使没有临床体征，其存在也必须促使医生筛查相关癌症。
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