Arilla E, Hernandez M, Polanco I, Roca B, Prieto J C, Vazquez C
Department of Biochemistry, University of Alcala de Henares, Madrid, Spain.
J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):228-33. doi: 10.1097/00005176-198703000-00012.
The concentration of somatostatin was studied in controls as well as in plasma and jejunal mucosa from celiac children with and without jejunal villous atrophy. The binding of somatostatin to cytosolic fraction, isolated from jejunal mucosa from celiac patients and controls, was also investigated. Fasting plasma somatostatin concentrations were not significantly different among the various groups studied. However, the jejunal somatostatin content was significantly higher in the group of celiac children with subtotal villous atrophy as compared to control group and celiac children with normal villous architecture. The binding of somatostatin to cytosol of jejunal mucosa was significantly decreased in the group of celiac children with subtotal villous atrophy. The present results suggest that somatostatin may be involved in the pathophysiological processes of celiac disease.
研究了对照组以及患有和未患有空肠绒毛萎缩的乳糜泻儿童的血浆和空肠黏膜中生长抑素的浓度。还研究了生长抑素与从乳糜泻患者和对照组的空肠黏膜中分离出的胞质部分的结合情况。在研究的各个组中,空腹血浆生长抑素浓度没有显著差异。然而,与对照组和具有正常绒毛结构的乳糜泻儿童相比,患有部分绒毛萎缩的乳糜泻儿童组的空肠生长抑素含量显著更高。在患有部分绒毛萎缩的乳糜泻儿童组中,生长抑素与空肠黏膜胞质溶胶的结合显著减少。目前的结果表明,生长抑素可能参与了乳糜泻的病理生理过程。