患有活动性疾病且接受激发试验饮食的乳糜泻患儿空肠活检标本中的类前列腺素。放射免疫分析评估。

Prostanoids in jejunal biopsy specimens of celiac children with active disease and on challenge diet. Radioimmunologic evaluation.

作者信息

Pietroletti R, Castro M, Mariani P, Lucidi V, D'Alessandro M D, Carlei F, Lomanto D, Lezoche E, Speranza V

机构信息

Institute of the IInd Surgical Clinic, La Sapienza University, Rome, Italy.

出版信息

Scand J Gastroenterol. 1987 Dec;22(10):1181-4. doi: 10.3109/00365528708996461.

DOI:10.3109/00365528708996461

PMID:3481115

Abstract

Prostanoid generation (prostaglandin E2 and thromboxane B2) in jejunal biopsy specimens from celiac patients was evaluated, comparing celiac patients with celiac patients on challenge diet and controls. Generation of prostaglandin E2 in jejunal specimens from 14 children with active celiac disease was significantly higher (341.8 +/- 82.3 ng/g; mean +/- SEM) than that from 7 celiac patients on gluten challenge diet (69.4 +/- 13.2 ng/g) or 8 normal children (92 +/- 23 ng/g) (p less than 0.05). In contrast, thromboxane B2 generation in jejunal specimens from all three groups did not show any statistically significant variation. Our results indicate that prostaglandin E2 generation is not merely related to the activity of clinical symptoms, since patients receiving gluten challenge had prostaglandin E2 levels that did not differ from those of controls.

摘要

对乳糜泻患者空肠活检标本中的类前列腺素生成（前列腺素E2和血栓素B2）进行了评估，将乳糜泻患者与接受激发饮食的乳糜泻患者及对照组进行了比较。14名患有活动性乳糜泻的儿童空肠标本中前列腺素E2的生成量（341.8±82.3 ng/g；平均值±标准误）显著高于7名接受麸质激发饮食的乳糜泻患者（69.4±13.2 ng/g）或8名正常儿童（92±23 ng/g）（p<0.05）。相比之下，三组空肠标本中血栓素B2的生成量未显示出任何统计学上的显著差异。我们的结果表明，前列腺素E2的生成不仅仅与临床症状的活动有关，因为接受麸质激发的患者的前列腺素E2水平与对照组无异。