Centro di Riferimento Oncologico, IRCCS Istituto Nazionale Tumori, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Humanitas Mater Domini, Castellanza, Italy.
Support Care Cancer. 2018 Feb;26(2):651-656. doi: 10.1007/s00520-017-3880-8. Epub 2017 Sep 16.
Understanding the quality of life (QoL) of cancer survivors is relevant to both clinical practice and health care policy. The current study compared the QoL profile in this specific population with that of a normative sample for the general population, as well as with those of both healthy and oncological patients normative sub-samples. In addition, associations between the obtained QoL profile and the main socio-demographic and clinical characteristics of the sample were examined.
Three hundred and ninety-two adult long-term cancer survivors (i.e., people 5 + years from their cancer diagnosis who were free from it and its treatments) were enrolled during follow-up visits and compiled the Short Form 36 Health Survey.
In comparison with the normative data for the adult general population, the present sample showed lower scores in Physical functioning, Role-physical limitation, and Role-emotional limitations (all differences were both statistically and clinically significant); the difference in Vitality was only statistically significant. In all eight SF-36 scales, scores of the present sample were clinically and statistically lower than those of the normative healthy subsample, whereas they were statistically and clinically higher than those of normative subsample which had experienced cancer, except for Role-physical limitation. The QoL profile was associated with gender (p = 0.002), age (p = 0.001), education (p < 0.001), occupational status (p < 0.001), and the presence of other health issues (p < 0.001).
These data support the utility of rehabilitative programs which integrate both healthcare and social interventions. In addition, they encourage the monitoring of the health status of this specific population, within a broad frame which simultaneously takes into consideration health and QoL.
了解癌症幸存者的生活质量（QoL）与临床实践和医疗保健政策都息息相关。本研究比较了该特定人群的 QoL 特征与一般人群的参考样本，以及健康和肿瘤患者的参考子样本。此外，还研究了获得的 QoL 特征与样本的主要社会人口学和临床特征之间的关系。
在随访期间招募了 392 名成年长期癌症幸存者（即癌症诊断后 5 岁及以上且无癌症及其治疗的人），并填写了简短形式 36 健康调查。
与成人一般人群的参考数据相比，本样本在身体机能、身体角色限制和情绪角色限制方面的得分较低（所有差异均具有统计学和临床意义）；活力方面的差异仅具有统计学意义。在所有 8 个 SF-36 量表中，本样本的评分在临床和统计学上均低于健康参考子样本，而高于经历过癌症的参考子样本，除身体角色限制外。QoL 特征与性别（p=0.002）、年龄（p=0.001）、教育（p<0.001）、职业状况（p<0.001）和其他健康问题的存在（p<0.001）有关。
这些数据支持整合医疗保健和社会干预的康复计划的实用性。此外，它们鼓励在广泛的框架内监测这一特定人群的健康状况，同时考虑健康和 QoL。
