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低蛋白补充饮食的慢性肾脏病患者成功妊娠:对墨西哥这一新兴国家的慢性肾脏病和妊娠问题的反思。

Successful pregnancy in a CKD patient on a low-protein, supplemented diet: an opportunity to reflect on CKD and pregnancy in Mexico, an emerging country.

机构信息

Centro de Atencion Nutricional Fresenius Kabi, Dante 36, 3er Piso, Colonia Anzures, Delegacion Miguel Hidalgo, Ciudad de Mexico, Mexico.

Instituto Nacional de Perinatología Isidro Espinosa de los Reyes (INPER), Calle Montes Urales 800, Ciudad de Mexico, Mexico.

出版信息

J Nephrol. 2017 Dec;30(6):877-882. doi: 10.1007/s40620-017-0428-4. Epub 2017 Sep 16.

Abstract

Pregnancy is probably the most important challenge in young women with chronic kidney disease (CKD). The challenge is greater in developing countries, in which access to dialysis is uneven, and prenatal care for CKD patients is not uniformly available. This case report summarizes some of the challenges faced by pregnant CKD women in a developing country. A 35-year-old woman, affected by an undiagnosed kidney disease, experienced preeclampsia at 24 years of age, and started dialysis in emergency at age 31 in the context of severe preeclampsia in her second pregnancy. Following slow recovery of kidney function, after 18 months of dialysis she started a moderately restricted, supplemented, low-protein diet, which allowed her to discontinue dialysis. A few months after dialysis discontinuation, she started a new pregnancy in the presence of severely reduced kidney function (serum creatinine 4.6 mg/dl at the last pre-pregnancy control). Interestingly, she discontinued nephrology and nutritional follow-up, mainly because she was worried that she would be discouraged from continuing the pregnancy, but also because she continued to feel well. She self-managed her diet in pregnancy and delivered a healthy baby, with normal intrauterine growth, at term; while the last laboratory data confirmed the presence of severe kidney function impairment, she is still dialysis-free at the time of the present report. Her story, with its happy ending, underlines the importance of dedicated programs for CKD pregnancies in developing countries and confirms the safety of moderately protein-restricted diets in pregnancy.

摘要

妊娠可能是慢性肾脏病(CKD)年轻女性面临的最重要挑战。在发展中国家,挑战更大,因为这些国家的透析机会不均等,CKD 患者的产前护理也不是普遍提供的。本病例报告总结了发展中国家妊娠 CKD 女性所面临的一些挑战。一名 35 岁的女性患有未确诊的肾脏疾病,在 24 岁时出现子痫前期,并在第二次妊娠时因严重子痫前期在 31 岁时紧急开始透析。在肾功能缓慢恢复后,她在透析 18 个月后开始接受适度限制、补充、低蛋白饮食,这使她能够停止透析。在透析停止数月后,在肾功能严重下降(上次妊娠前检查时血清肌酐 4.6mg/dl)的情况下,她开始了新的妊娠。有趣的是,她停止了肾脏病学和营养随访,主要是因为她担心会被劝阻继续妊娠,但也因为她继续感觉良好。她在妊娠期间自行管理饮食,并足月分娩了一个健康的婴儿,宫内生长正常;虽然最后一次实验室数据证实存在严重的肾功能损害,但在本报告时,她仍无需透析。她的故事以圆满结局为特色,强调了发展中国家针对 CKD 妊娠的专门计划的重要性,并证实了妊娠期间适度限制蛋白质饮食的安全性。

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