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竖脊肌平面(ESP)阻滞在开胸术后疼痛综合征管理中的应用:病例系列

Erector spinae plane (ESP) block in the management of post thoracotomy pain syndrome: A case series.

作者信息

Forero Mauricio, Rajarathinam Manikandan, Adhikary Sanjib, Chin Ki Jinn

机构信息

Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.

Department of Anesthesia, Penn State Hershey Medical Center, Hershey, PA, USA.

出版信息

Scand J Pain. 2017 Oct;17:325-329. doi: 10.1016/j.sjpain.2017.08.013. Epub 2017 Sep 12.

Abstract

BACKGROUND AND AIMS

Post thoracotomy pain syndrome (PTPS) remains a common complication of thoracic surgery with significant impact on patients' quality of life. Management usually involves a multidisciplinary approach that includes oral and topical analgesics, performing appropriate interventional techniques, and coordinating additional care such as physiotherapy, psychotherapy and rehabilitation. A variety of interventional procedures have been described to treat PTPS that is inadequately managed with systemic or topical analgesics. Most of these procedures are technically complex and are associated with risks and complications due to the proximity of the targets to neuraxial structures and pleura. The ultrasound-guided erector spinae plane (ESP) block is a novel technique for thoracic analgesia that promises to be a relatively simple and safe alternative to more complex and invasive techniques of neural blockade. We have explored the application of the ESP block in the management of PTPS and report our preliminary experience to illustrate its therapeutic potential.

METHODS

The ESP block was performed in a pain clinic setting in a cohort of 7 patients with PTPS following thoracic surgery with lobectomy or pneumonectomy for lung cancer. The blocks were performed with ultrasound guidance by injecting 20-30mL of ropivacaine, with or without steroid, into a fascial plane between the deep surface of erector spinae muscle and the transverse processes of the thoracic vertebrae. This paraspinal tissue plane is distant from the pleura and the neuraxis, thus minimizing the risk of complications associated with injury to these structures. The patients were followed up by telephone one week after each block and reviewed in the clinic 4-6 weeks later to evaluate the analgesic response as well as the need for further injections and modification to the overall analgesic plan.

RESULTS

All the patients had excellent immediate pain relief following each ESP block, and 4 out of the 7 patients experienced prolonged analgesic benefit lasting 2 weeks or more. The ESP blocks were combined with optimization of multimodal analgesia, resulting in significant improvement in the pain experience in all patients. No complications related to the blocks were seen.

CONCLUSION

The results observed in this case series indicate that the ESP block may be a valuable therapeutic option in the management of PTPS. Its immediate analgesic efficacy provides patients with temporary symptomatic relief while other aspects of chronic pain management are optimized, and it may also often confer prolonged analgesia.

IMPLICATIONS

The relative simplicity and safety of the ESP block offer advantages over other interventional procedures for thoracic pain; there are few contraindications, the risk of serious complications (apart from local anesthetic systemic toxicity) is minimal, and it can be performed in an outpatient clinic setting. This, combined with the immediate and profound analgesia that follows the block, makes it an attractive option in the management of intractable chronic thoracic pain. The ESP block may also be applied to management of acute pain management following thoracotomy or thoracic trauma (e.g. rib fractures), with similar analgesic benefits expected. Further studies to validate our observations are warranted.

摘要

背景与目的

开胸术后疼痛综合征(PTPS)仍是胸外科手术常见的并发症,对患者生活质量有重大影响。治疗通常采用多学科方法,包括口服和外用镇痛药、采用适当的介入技术,以及协调额外的护理,如物理治疗、心理治疗和康复治疗。已经描述了多种介入手术来治疗经全身或外用镇痛药治疗效果不佳的PTPS。这些手术大多技术复杂,且由于靶点靠近神经轴结构和胸膜,存在风险和并发症。超声引导下竖脊肌平面(ESP)阻滞是一种新型的胸部镇痛技术,有望成为比更复杂、侵入性更强的神经阻滞技术相对简单且安全的替代方法。我们探讨了ESP阻滞在PTPS治疗中的应用,并报告我们的初步经验以说明其治疗潜力。

方法

在疼痛门诊对7例因肺癌行肺叶切除术或全肺切除术的PTPS患者进行ESP阻滞。在超声引导下,将20 - 30mL罗哌卡因(加或不加类固醇)注入竖脊肌深面与胸椎横突之间的筋膜平面。这个椎旁组织平面远离胸膜和神经轴,从而将与这些结构损伤相关的并发症风险降至最低。每次阻滞后1周通过电话对患者进行随访,并在4 - 6周后到门诊复查,以评估镇痛效果以及是否需要进一步注射和调整整体镇痛方案。

结果

每次ESP阻滞后所有患者均立即获得良好的疼痛缓解,7例患者中有4例获得了持续2周或更长时间的延长镇痛效果。ESP阻滞与多模式镇痛的优化相结合,使所有患者的疼痛体验均有显著改善。未观察到与阻滞相关的并发症。

结论

本病例系列观察结果表明,ESP阻滞可能是PTPS治疗中有价值的治疗选择。其即时镇痛效果为患者提供了暂时的症状缓解,同时优化了慢性疼痛管理的其他方面,并且通常还可提供延长的镇痛效果。

意义

ESP阻滞相对简单和安全,优于其他胸部疼痛介入手术;禁忌证少,严重并发症(除局部麻醉药全身毒性外)风险极小,且可在门诊进行。这与阻滞后立即产生的深度镇痛相结合,使其成为治疗顽固性慢性胸痛的有吸引力的选择。ESP阻滞也可应用于开胸术后或胸部创伤(如肋骨骨折)后的急性疼痛管理,预期有类似的镇痛效果。有必要进行进一步研究以验证我们的观察结果。

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