Begum A, Baten M A, Begum Z, Ahsan M M, Rahman S F, Chowdhury F, Khan A H
Dr Ambia Begum, Assistant Professor, Department of Pathology, Community Based Medical College Bangladesh (CBMCB), Mymensingh, Bangladesh.
Mymensingh Med J. 2017 Jul;26(3):628-634.
In spite of the global decline in its incidence and mortality, gastric carcinoma still remains a major cause of death due to cancer. Early detection of gastric carcinoma is expected to reduce mortality rates. The applications of measuring of pepsinogen I and pepsinogen II are useful in screening of gastric carcinoma. This cross sectional comparative study was done to find out the correlation of histopathological pattern of gastric carcinoma with serum pepsinogen I & II ratio in the Department of Pathology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh from January 2010 to December 2010. For these purpose 40 patients with gastric carcinoma, endoscopically visible and histopathologically proved malignant lesions were enrolled as case group. Forty subjects with normal upper GI endoscopy were taken as control. Five ml of venous blood was taken from both case and control subjects to determine serum pepsinogen I and pepsinogen II level by ELISA method, subsequently pepsinogen I and II ratio was calculated. In this study different cut off values of serum pepsinogen I and II ratio was determined and the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 70.0%, 97.5% 96.6% 76.5% and 83.8% respectively, at cut off value of 6. Which is the most suitable cut off point of serum pepsinogen I and II ratio for gastric cancer screening.
尽管全球胃癌的发病率和死亡率有所下降，但它仍然是癌症死亡的主要原因。早期发现胃癌有望降低死亡率。胃蛋白酶原I和胃蛋白酶原II检测的应用有助于胃癌筛查。本横断面比较研究于2010年1月至2010年12月在孟加拉国锡尔赫特MAG奥斯曼尼医学院病理科进行，旨在找出胃癌组织病理学模式与血清胃蛋白酶原I和II比值之间的相关性。为此，将40例经内镜可见且组织病理学证实为恶性病变的胃癌患者纳入病例组。选取40例上消化道内镜检查正常的受试者作为对照组。从病例组和对照组受试者中各采集5毫升静脉血，采用酶联免疫吸附测定法测定血清胃蛋白酶原I和胃蛋白酶原II水平，随后计算胃蛋白酶原I和II的比值。本研究确定了血清胃蛋白酶原I和II比值的不同临界值，在临界值为6时，其灵敏度、特异度、阳性预测值、阴性预测值和准确度分别为70.0%、97.5%、96.6%、76.5%和83.8%。这是用于胃癌筛查的血清胃蛋白酶原I和II比值的最合适临界值。
